CD274 and VLDLR

		CD274	VLDLR
Description		CD274 molecule	very low density lipoprotein receptor
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GO Annotations	Cellular Component	Nucleoplasm Plasma Membrane External Side Of Plasma Membrane Actin Cytoskeleton Integral Component Of Membrane Early Endosome Membrane Recycling Endosome Membrane Extracellular Exosome	Lysosomal Membrane Plasma Membrane Clathrin-coated Pit Membrane Integral Component Of Membrane Very-low-density Lipoprotein Particle Receptor Complex
	Molecular Function	Protein Binding	Low-density Lipoprotein Particle Receptor Activity Calcium Ion Binding Protein Binding Very-low-density Lipoprotein Particle Receptor Activity Apolipoprotein Binding Very-low-density Lipoprotein Particle Binding Cargo Receptor Activity Reelin Receptor Activity Calcium-dependent Protein Binding
	Biological Process	Adaptive Immune Response Positive Regulation Of Tolerance Induction To Tumor Cell Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Migration T Cell Costimulation Negative Regulation Of Interferon-gamma Production Negative Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-10 Production Response To Cytokine Positive Regulation Of T Cell Proliferation Negative Regulation Of T Cell Proliferation Regulation Of Activated T Cell Proliferation Negative Regulation Of Activated T Cell Proliferation Regulation Of T Cell Apoptotic Process Cellular Response To Lipopolysaccharide Toxin Transport Negative Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Regulation Of Activated CD4-positive, Alpha-beta T Cell Apoptotic Process Positive Regulation Of Activated CD8-positive, Alpha-beta T Cell Apoptotic Process Negative Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Negative Regulation Of CD8-positive, Alpha-beta T Cell Activation	Lipid Transport Receptor-mediated Endocytosis Signal Transduction Nervous System Development Memory Cholesterol Metabolic Process Ventral Spinal Cord Development Glycoprotein Transport Very-low-density Lipoprotein Particle Clearance Reelin-mediated Signaling Pathway Positive Regulation Of Protein Kinase Activity Dendrite Morphogenesis Positive Regulation Of Dendrite Development
Pathways		PD-1 signaling STAT3 nuclear events downstream of ALK signaling	Reelin signalling pathway VLDLR internalisation and degradation VLDL clearance
Drugs		Atezolizumab Durvalumab Avelumab Envafolimab Cosibelimab AUNP-12 CA-170 anti-OX40 antibody BMS 986178	Lauric acid
Diseases
GWAS		Blood protein levels ( 30072576)	Alzheimer's disease (age of onset) ( 22005931) Apolipoprotein B levels ( 32203549) Cholesterol, total ( 24097068) Cytokine levels ( 31679650) Cytokine network levels (multivariate analysis) ( 31679650) Gambling ( 22780124) Hematocrit ( 32888494 27863252) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Inflammatory biomarkers (multivariate analysis) ( 33110245) LDL cholesterol ( 24097068 30275531) LDL cholesterol levels ( 32203549 28334899) Low density lipoprotein cholesterol levels ( 32154731) Lymphocyte percentage of white cells ( 32888494) Monocyte count ( 32888494) Neutrophil count ( 32888494) Platelet count ( 32888494) Plateletcrit ( 32888494) Red blood cell count ( 32888494) Systolic blood pressure ( 26969751) Total cholesterol levels ( 30275531) Vascular endothelial growth factor levels ( 26910538 27989323 31217265 21757650) White blood cell count ( 32888494) White coat effect (clinic diastolic blood pressure minus ambulatory diastolic blood pressure) ( 31044621)
Interacting Genes		6 interacting genes: CD80 COPS5 CREB1 OTUB1 PDCD1 VLDLR	12 interacting genes: APOE CD274 CD36 CLU DAB1 ITSN1 LPL LRPAP1 MYLIP RELN SNX17 ZSCAN12
Entrez ID		29126	7436
HPRD ID		05655	01895
Ensembl ID		ENSG00000120217	ENSG00000147852
Uniprot IDs		Q0GN75 Q9NZQ7	P98155 Q5VVF5
PDB IDs		3BIK 3BIS 3FN3 3SBW 4Z18 4ZQK 5C3T 5GGT 5GRJ 5IUS 5J89 5J8O 5JDR 5JDS 5N2D 5N2F 5NIU 5O45 5O4Y 5X8L 5X8M 5XJ4 5XXY 6L8R 6NM7 6NM8 6NNV 6NOJ 6NOS 6NP9 6PV9 6R3K 6RPG 6VQN 6YCR	1V9U 3DPR 6BYV
Enriched GO Terms of Interacting Partners?
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