CD274

Description		CD274 molecule
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GO Annotations	Cellular Component	Nucleoplasm Plasma Membrane External Side Of Plasma Membrane Actin Cytoskeleton Integral Component Of Membrane Early Endosome Membrane Recycling Endosome Membrane Extracellular Exosome
	Molecular Function	Protein Binding
	Biological Process	Adaptive Immune Response Positive Regulation Of Tolerance Induction To Tumor Cell Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Migration T Cell Costimulation Negative Regulation Of Interferon-gamma Production Negative Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-10 Production Response To Cytokine Positive Regulation Of T Cell Proliferation Negative Regulation Of T Cell Proliferation Regulation Of Activated T Cell Proliferation Negative Regulation Of Activated T Cell Proliferation Regulation Of T Cell Apoptotic Process Cellular Response To Lipopolysaccharide Toxin Transport Negative Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Regulation Of Activated CD4-positive, Alpha-beta T Cell Apoptotic Process Positive Regulation Of Activated CD8-positive, Alpha-beta T Cell Apoptotic Process Negative Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Negative Regulation Of CD8-positive, Alpha-beta T Cell Activation
Pathways		PD-1 signaling STAT3 nuclear events downstream of ALK signaling
Drugs		Atezolizumab Durvalumab Avelumab Envafolimab Cosibelimab AUNP-12 CA-170 anti-OX40 antibody BMS 986178
Diseases
GWAS		Blood protein levels ( 30072576)
Interacting Genes		6 interacting genes: CD80 COPS5 CREB1 OTUB1 PDCD1 VLDLR
Entrez ID		29126
HPRD ID		05655
Ensembl ID		ENSG00000120217
Uniprot IDs		Q0GN75 Q9NZQ7
PDB IDs		3BIK 3BIS 3FN3 3SBW 4Z18 4ZQK 5C3T 5GGT 5GRJ 5IUS 5J89 5J8O 5JDR 5JDS 5N2D 5N2F 5NIU 5O45 5O4Y 5X8L 5X8M 5XJ4 5XXY 6L8R 6NM7 6NM8 6NNV 6NOJ 6NOS 6NP9 6PV9 6R3K 6RPG 6VQN 6YCR
Enriched GO Terms of Interacting Partners?
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