ECSIT and GCDH

Number of citations of the paper that reports this interaction (PubMedID 21163940)
36

Data Source:
BioGRID (two hybrid)

		ECSIT	GCDH
Description		ECSIT signaling integrator	glutaryl-CoA dehydrogenase
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Inner Membrane Cytosol	Mitochondrion Mitochondrial Matrix
	Molecular Function	Protein Binding	Fatty-acyl-CoA Binding Glutaryl-CoA Dehydrogenase Activity Flavin Adenine Dinucleotide Binding
	Biological Process	Innate Immune Response Regulation Of Oxidoreductase Activity Regulation Of Protein Complex Stability	Tryptophan Metabolic Process Fatty Acid Beta-oxidation Using Acyl-CoA Dehydrogenase Fatty-acyl-CoA Biosynthetic Process
Pathways		MyD88:MAL(TIRAP) cascade initiated on plasma membrane Complex I biogenesis TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88 cascade initiated on plasma membrane	Lysine catabolism
Drugs			Flavin adenine dinucleotide S-4-Nitrobutyryl-CoA
Diseases
GWAS		Presence of antiphospholipid antibodies ( 27098658)	Blood metabolite levels ( 24816252) Clozapine-induced agranulocytosis ( 25187353) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Mean corpuscular hemoglobin ( 32888494 27863252 19862010) Mean corpuscular hemoglobin concentration ( 32888494 27863252) Mean corpuscular volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 32888494 27863252) Red cell distribution width ( 32888494) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252) Serum metabolite levels ( 33031748)
Interacting Genes		61 interacting genes: A2M AP1M2 APOE APP BFSP2 BLMH C1orf109 CDC37 CEP55 CNN1 CORO2B CTNNA3 CYP2C18 CYP2C8 CYP2C9 DNAJB1 DTX2 DYNC1H1 ELAVL3 EXOC6 EXOSC1 FARSA FBXL12 FBXW4 GCDH GEM IFIT3 IFIT5 IMMT LONP1 LOXL4 MAGEB2 MARCHF2 MAST1 MKRN3 MRPL4 NDUFA13 NFKB1 NXF1 OGT PAXIP1 PI4K2A PRDX2 PSEN1 RAB3A RAD23A RELA RHEB RNF32 SELPLG SETDB1 SHFL SMAD1 SMAD4 SMURF1 STAMBPL1 STRN4 TARS3 TRAF6 TRIM59 TSSK3	13 interacting genes: A2M ADCY2 APOE CDC37 DNM2 ECSIT EXOC6 MAST1 NOS3 PSEN1 PSEN2 RNF32 THTPA
Entrez ID		51295	2639
HPRD ID		12225	01977
Ensembl ID		ENSG00000130159	ENSG00000105607
Uniprot IDs		Q9BQ95	A0A024R7F9 Q92947
PDB IDs			1SIQ 1SIR 2R0M 2R0N
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?