ECSIT and TSSK3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		ECSIT	TSSK3
Description		ECSIT signaling integrator	testis specific serine kinase 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Inner Membrane Cytosol
	Molecular Function	Protein Binding	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Serine Kinase Activity
	Biological Process	Innate Immune Response Regulation Of Oxidoreductase Activity Regulation Of Protein Complex Stability	Protein Phosphorylation Spermatogenesis Cell Differentiation Intracellular Signal Transduction
Pathways		MyD88:MAL(TIRAP) cascade initiated on plasma membrane Complex I biogenesis TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88 cascade initiated on plasma membrane
Drugs
Diseases
GWAS		Presence of antiphospholipid antibodies ( 27098658)	Pre-treatment viral load in HIV-1 infection ( 31219150)
Interacting Genes		61 interacting genes: A2M AP1M2 APOE APP BFSP2 BLMH C1orf109 CDC37 CEP55 CNN1 CORO2B CTNNA3 CYP2C18 CYP2C8 CYP2C9 DNAJB1 DTX2 DYNC1H1 ELAVL3 EXOC6 EXOSC1 FARSA FBXL12 FBXW4 GCDH GEM IFIT3 IFIT5 IMMT LONP1 LOXL4 MAGEB2 MARCHF2 MAST1 MKRN3 MRPL4 NDUFA13 NFKB1 NXF1 OGT PAXIP1 PI4K2A PRDX2 PSEN1 RAB3A RAD23A RELA RHEB RNF32 SELPLG SETDB1 SHFL SMAD1 SMAD4 SMURF1 STAMBPL1 STRN4 TARS3 TRAF6 TRIM59 TSSK3	67 interacting genes: ADAMTSL4 ARID5A ATP23 C15orf48 C2CD6 C9orf24 CENPN DDIT4L DRG2 ECSIT EFHC2 EYA2 FUT9 GOLGA2 GP2 IKZF3 INCA1 KRT75 KRTAP13-2 KRTAP13-3 LBX1 LHX3 LMO2 LNX1 LZTS2 MBD3L1 MEI4 MRPL28 MSX2 MYOG MYOZ3 NFKBID NME4 OIP5 PBX4 PJA1 PLEKHG4 PPP1R16A PRDM6 RBBP4 RBCK1 REL RIN3 RUSC1 SHISA6 SLAIN1 SMAD4 STAT5B SYNGAP1 TCF4 TCP10L TEPSIN TGM7 TLE5 TRIM35 TRIM50 TRIM54 TRIM9 TRIP6 UROD USP54 VGLL1 VPS52 YJU2B YPEL3 ZBTB25 ZMYND12
Entrez ID		51295	81629
HPRD ID		12225	09635
Ensembl ID		ENSG00000130159	ENSG00000162526
Uniprot IDs		Q9BQ95	Q96PN8
PDB IDs
Enriched GO Terms of Interacting Partners?
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