GCDH and ADCY2

		GCDH	ADCY2
Description		glutaryl-CoA dehydrogenase	adenylate cyclase 2
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Membrane Dendrite Membrane Raft
	Molecular Function	Fatty-acyl-CoA Binding Glutaryl-CoA Dehydrogenase Activity Flavin Adenine Dinucleotide Binding	Magnesium Ion Binding Adenylate Cyclase Activity ATP Binding Adenylate Cyclase Binding Manganese Ion Binding
	Biological Process	Tryptophan Metabolic Process Fatty Acid Beta-oxidation Using Acyl-CoA Dehydrogenase Fatty-acyl-CoA Biosynthetic Process	CAMP Biosynthetic Process Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway CAMP-mediated Signaling Cellular Response To Forskolin
Pathways		Lysine catabolism	Glucagon signaling in metabolic regulation PKA activation PKA activation in glucagon signalling Adenylate cyclase activating pathway Adenylate cyclase inhibitory pathway Adenylate cyclase inhibitory pathway G alpha (s) signalling events G alpha (s) signalling events G alpha (i) signalling events G alpha (z) signalling events G alpha (z) signalling events Vasopressin regulates renal water homeostasis via Aquaporins Hedgehog 'off' state ADORA2B mediated anti-inflammatory cytokines production ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis
Drugs		Flavin adenine dinucleotide S-4-Nitrobutyryl-CoA	Colforsin 2',5'-DIDEOXY-ADENOSINE 3'-MONOPHOSPHATE Aurothioglucose
Diseases
GWAS		Blood metabolite levels ( 24816252) Clozapine-induced agranulocytosis ( 25187353) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Mean corpuscular hemoglobin ( 32888494 27863252 19862010) Mean corpuscular hemoglobin concentration ( 32888494 27863252) Mean corpuscular volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 32888494 27863252) Red cell distribution width ( 32888494) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252) Serum metabolite levels ( 33031748)	Anxiety and stress-related disorders ( 31116379) Atorvastatin-induced myopathy ( 31220337) Bipolar disorder ( 24618891 31043756) Bipolar disorder (age of onset <21) or attention deficit hyperactivity disorder ( 27890468) Bipolar disorder or attention deficit hyperactivity disorder ( 27890468) Bipolar I disorder ( 31043756) Caffeine consumption from coffee ( 33287642) Caffeine consumption from coffee or tea ( 33287642) Capecitabine sensitivity ( 22864933) Coffee consumption ( 31046077) Cognitive decline rate in late mild cognitive impairment ( 26252872) Food addiction ( 27106561) LDL cholesterol levels in HIV infection ( 33109212) Mean arterial pressure (alcohol consumption interaction) ( 24376456) Oropharynx cancer ( 27749845) Pars opercularis volume ( 31530798) Plasma factor VII activating protease levels ( 30070759) Posterior-cingulate cortex volume ( 31530798) Smoking status (heavy vs never) ( 26423011) Visceral fat ( 22589738)
Interacting Genes		13 interacting genes: A2M ADCY2 APOE CDC37 DNM2 ECSIT EXOC6 MAST1 NOS3 PSEN1 PSEN2 RNF32 THTPA	14 interacting genes: ADCY1 ADCY5 AHRR CDH18 DRD4 F2RL1 GCDH GNAS GNG2 ISL1 NUF2 OBP2A RDH12 SLC9A3
Entrez ID		2639	108
HPRD ID		01977	00052
Ensembl ID		ENSG00000105607	ENSG00000078295
Uniprot IDs		A0A024R7F9 Q92947	Q08462 Q71UM8
PDB IDs		1SIQ 1SIR 2R0M 2R0N
Enriched GO Terms of Interacting Partners?
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