ACP6 and MAP3K8

		ACP6	MAP3K8
Description		acid phosphatase 6, lysophosphatidic	mitogen-activated protein kinase kinase kinase 8
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GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Matrix	Cytosol
	Molecular Function	Acid Phosphatase Activity Phosphatase Activity Lysophosphatidic Acid Phosphatase Activity	Magnesium Ion Binding Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Protein Serine Kinase Activity
	Biological Process	Hematopoietic Progenitor Cell Differentiation Phospholipid Metabolic Process Phosphatidic Acid Biosynthetic Process Dephosphorylation Lysobisphosphatidic Acid Metabolic Process	MAPK Cascade Protein Phosphorylation Cell Cycle T Cell Costimulation
Pathways		Synthesis of PA	CD28 dependent PI3K/Akt signaling MAP3K8 (TPL2)-dependent MAPK1/3 activation MAP3K8 (TPL2)-dependent MAPK1/3 activation
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Methotrexate-induced interstitial lung disease in rheumatoid arthritis ( 28500057)	Asthma ( 32296059) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908 23128233) Systemising ( 31508503) Ulcerative colitis ( 28067908)
Interacting Genes		4 interacting genes: FAM9B GNG7 MAP3K8 SLC35F6	26 interacting genes: ACP6 ACY3 ADAM10 AKT1 BMPR2 CD40 CHUK GAD2 JCAD LYZL2 MAP2K1 MAP2K4 MAP3K14 MTPAP NFKB1 NFKB2 PARD3 PDK2 RANGAP1 REL RELA RIPK1 STIP1 TNIP2 TRAF2 TRAF6
Entrez ID		51205	1326
HPRD ID		16472	01863
Ensembl ID		ENSG00000162836	ENSG00000107968
Uniprot IDs		Q9NPH0	P41279 Q6FG25
PDB IDs		4JOB 4JOC 4JOD	4Y83 4Y85 5IU2
Enriched GO Terms of Interacting Partners?
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