TNNI3K and ACTC1

Number of citations of the paper that reports this interaction (PubMedID 12721663)
20

Data Source:
HPRD (two hybrid)

		TNNI3K	ACTC1
Description		TNNI3 interacting kinase	actin alpha cardiac muscle 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm	Extracellular Space Cytoplasm Cytosol Dynactin Complex Actin Filament Focal Adhesion Membrane Sarcomere Lamellipodium Filopodium I Band Cell Body Extracellular Exosome Blood Microparticle
	Molecular Function	Protein Kinase Activity Protein Binding ATP Binding Protein C-terminus Binding Troponin I Binding Metal Ion Binding Protein Serine Kinase Activity	Microfilament Motor Activity ATP Binding Myosin Binding
	Biological Process	Regulation Of Heart Rate Protein Phosphorylation Regulation Of Cardiac Muscle Contraction Bundle Of His Cell To Purkinje Myocyte Communication Regulation Of Cardiac Conduction	Actin Filament Organization Response To Xenobiotic Stimulus Positive Regulation Of Gene Expression Actin Filament-based Movement Skeletal Muscle Thin Filament Assembly Actomyosin Structure Organization Actin-myosin Filament Sliding Response To Ethanol Cardiac Myofibril Assembly Cardiac Muscle Tissue Morphogenesis Heart Contraction Cardiac Muscle Contraction Mesenchyme Migration
Pathways			Striated Muscle Contraction RHOA GTPase cycle RHOB GTPase cycle
Drugs		Fostamatinib
Diseases
GWAS		Adult body size ( 32376654) Age at first sexual intercourse ( 34211149) BMI (adjusted for smoking behaviour) ( 28443625) Body mass index ( 26426971 23669352 28892062 20935630 28448500) Body mass index (age <50) ( 26426971) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index in physically active individuals ( 28448500) Body mass index x age interaction ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Body size at age 10 ( 32376654) Childhood body mass index ( 33045005 26604143) Hip circumference ( 25673412) Menarche (age at onset) ( 27182965 25231870) Mental health study participation (completed survey) ( 31263887) Obesity ( 23563607) Parental longevity (combined parental age at death) ( 29227965) Pubertal anthropometrics ( 23449627) Smoking initiation ( 30617275 33082346) Smoking initiation (ever regular vs never regular) ( 30679032)	Axial length ( 24144296) Refractive error ( 32231278 20835239)
Interacting Genes		8 interacting genes: ACTA1 ACTC1 AIP FABP3 FBXO4 HADHB MYBPC3 TNNI3	42 interacting genes: ABLIM3 ABRA ACTB ACTN4 ACTR2 AFAP1 ANG ASH2L BCL11A C1QTNF9 CAPN1 CFL1 DMD DMTN DYNLL1 EZR FBXO7 FSCN1 GAPDH GC HSPB1 HSPB2 KAT14 KLHL17 KLHL2 KPTN LASP1 MIB2 MPC1 MYLK OGT PLEC PRKCE SCIN SLC4A1 SYNE1 SYNE2 TNNI3K TWF1 UBC WAS WIPF1
Entrez ID		51086	70
HPRD ID		18208	00015
Ensembl ID		ENSG00000116783	ENSG00000159251
Uniprot IDs		Q59H18	B3KPP5 P68032
PDB IDs		4YFF 4YFI 6B5J
Enriched GO Terms of Interacting Partners?
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