TNNI3K and MYBPC3

Number of citations of the paper that reports this interaction (PubMedID 12721663)
20

Data Source:
HPRD (two hybrid)

		TNNI3K	MYBPC3
Description		TNNI3 interacting kinase	myosin binding protein C3
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm	Cytosol Striated Muscle Myosin Thick Filament C Zone Sarcomere A Band Cardiac Myofibril
	Molecular Function	Protein Kinase Activity Protein Binding ATP Binding Protein C-terminus Binding Troponin I Binding Metal Ion Binding Protein Serine Kinase Activity	ATPase Activator Activity Actin Binding Protein Binding Structural Constituent Of Muscle Myosin Binding Titin Binding Myosin Heavy Chain Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Regulation Of Heart Rate Protein Phosphorylation Regulation Of Cardiac Muscle Contraction Bundle Of His Cell To Purkinje Myocyte Communication Regulation Of Cardiac Conduction	Heart Morphogenesis Regulation Of Striated Muscle Contraction Cell Adhesion Positive Regulation Of ATPase Activity Regulation Of Muscle Filament Sliding Regulation Of Catalytic Activity Ventricular Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Contraction
Pathways			Striated Muscle Contraction
Drugs		Fostamatinib
Diseases
GWAS		Adult body size ( 32376654) Age at first sexual intercourse ( 34211149) BMI (adjusted for smoking behaviour) ( 28443625) Body mass index ( 26426971 23669352 28892062 20935630 28448500) Body mass index (age <50) ( 26426971) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index in physically active individuals ( 28448500) Body mass index x age interaction ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Body size at age 10 ( 32376654) Childhood body mass index ( 33045005 26604143) Hip circumference ( 25673412) Menarche (age at onset) ( 27182965 25231870) Mental health study participation (completed survey) ( 31263887) Obesity ( 23563607) Parental longevity (combined parental age at death) ( 29227965) Pubertal anthropometrics ( 23449627) Smoking initiation ( 30617275 33082346) Smoking initiation (ever regular vs never regular) ( 30679032)	Alcohol consumption ( 31358974) Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Apolipoprotein A1 levels ( 32203549) Autism spectrum disorder or schizophrenia ( 28540026) Brain morphology (MOSTest) ( 32665545) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Experiencing mood swings ( 29500382) Fruit consumption ( 32066663) HDL cholesterol levels ( 32203549 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Intraocular pressure ( 30054594) Loneliness ( 29970889) Loneliness (MTAG) ( 29970889) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Monocyte count ( 32888494) Multiple sclerosis ( 31604244) Neuroticism ( 29255261) Pulse pressure ( 30578418) Refractive error ( 32231278) Thrombin generation potential phenotypes ( 24357727) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716)
Interacting Genes		8 interacting genes: ACTA1 ACTC1 AIP FABP3 FBXO4 HADHB MYBPC3 TNNI3	8 interacting genes: CAPN1 HSPB2 MYH9 NCF1 TNNI3K TRIM55 TRIM63 TTN
Entrez ID		51086	4607
HPRD ID		18208	02980
Ensembl ID		ENSG00000116783	ENSG00000134571
Uniprot IDs		Q59H18	A5YM48 Q14896
PDB IDs		4YFF 4YFI 6B5J	1GXE 1PD6 2AVG 2K1M 2MQ0 2MQ3 2V6H 3CX2 5K6P 6CXI 6CXJ 6G2T
Enriched GO Terms of Interacting Partners?
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