SERPINA5 and PLAT

Number of citations of the paper that reports this interaction (PubMedID 2551064)
20

Data Source:
BioGRID (pull down)
HPRD (in vivo)

		SERPINA5	PLAT
Description		serpin family A member 5	plasminogen activator, tissue type
Image
GO Annotations	Cellular Component	Acrosomal Membrane Extracellular Region Extracellular Space External Side Of Plasma Membrane Membrane Platelet Alpha Granule Platelet Dense Tubular Network Protein-containing Complex Protein C Inhibitor-TMPRSS7 Complex Protein C Inhibitor-TMPRSS11E Complex Protein C Inhibitor-PLAT Complex Protein C Inhibitor-PLAU Complex Protein C Inhibitor-thrombin Complex Protein C Inhibitor-KLK3 Complex Protein C Inhibitor-plasma Kallikrein Complex Collagen-containing Extracellular Matrix Extracellular Exosome Protein C Inhibitor-coagulation Factor V Complex Protein C Inhibitor-coagulation Factor Xa Complex Protein C Inhibitor-coagulation Factor XI Complex	Extracellular Region Extracellular Space Cytoplasm Cell Surface Secretory Granule Apical Part Of Cell Collagen-containing Extracellular Matrix Extracellular Exosome Schaffer Collateral - CA1 Synapse Glutamatergic Synapse
	Molecular Function	Retinoic Acid Binding Protease Binding Serine-type Endopeptidase Inhibitor Activity Protein Binding Glycosaminoglycan Binding Heparin Binding Phosphatidylcholine Binding Acrosin Binding	Serine-type Endopeptidase Activity Signaling Receptor Binding Protein Binding Phosphoprotein Binding
	Biological Process	Lipid Transport Spermatogenesis Fusion Of Sperm To Egg Plasma Membrane Involved In Single Fertilization Negative Regulation Of Endopeptidase Activity Negative Regulation Of Hydrolase Activity Seminal Vesicle Development	Response To Hypoxia Cellular Protein Modification Process Proteolysis Blood Coagulation Smooth Muscle Cell Migration Plasminogen Activation Fibrinolysis Negative Regulation Of Proteolysis Platelet-derived Growth Factor Receptor Signaling Pathway Prevention Of Polyspermy Trans-synaptic Signaling By BDNF, Modulating Synaptic Transmission
Pathways		Intrinsic Pathway of Fibrin Clot Formation Common Pathway of Fibrin Clot Formation	Signaling by PDGF Dissolution of Fibrin Clot
Drugs		Urokinase Drotrecogin alfa Tifuvirtide PPL-100	Aminocaproic acid Iloprost Human C1-esterase inhibitor 5-(DIMETHYLAMINO)-2-NAPHTHALENESULFONIC ACID Dexibuprofen Conestat alfa
Diseases
GWAS		Blood protein levels ( 30072576 29875488 28240269) Serum albumin level ( 29403010) Serum total protein level ( 29403010)	Blood protein levels ( 30072576) Plasma plasminogen activator levels ( 24578379) Systemic lupus erythematosus ( 28714469)
Interacting Genes		23 interacting genes: ACR CBL COPS6 EPS8 F10 F11 F2 FBLN5 FGA FGB FGG KLK1 KLK2 KLK3 KLKB1 PIAS4 PLAT PLAU PROC RCHY1 RIDA SEMG2 THBD	37 interacting genes: ANXA2 APP BAG4 CALR CKAP4 CLEC3B CRABP1 CRTC1 DDHD2 EIF4EBP1 F10 FGA FN1 GML GRIN1 HMGB1 KRT8 LAMA1 LAMA3 LRP1 LRP1B MAPK1 MAPK3 MTDH PDGFC PLAU PLG PPP2CB PVR SART1 SERPINA5 SERPINE1 SERPING1 SERPINI1 SLC28A2 SPARC VDAC1
Entrez ID		5104	5327
HPRD ID		03503	01419
Ensembl ID		ENSG00000188488	ENSG00000104368
Uniprot IDs		A0A024R6N9 B4DDH1 P05154	B4DN26 P00750
PDB IDs		1LQ8 1PAI 2HI9 2OL2 2PAI 3DY0	1A5H 1BDA 1PK2 1PML 1RTF 1TPG 1TPK 1TPM 1TPN 5BRR 5ZLZ
Enriched GO Terms of Interacting Partners?
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