PAK2 and SORBS3

Number of citations of the paper that reports this interaction (PubMedID 21516116)
114

Data Source:
BioGRID (two hybrid)
HPRD (in vitro)

		PAK2	SORBS3
Description		p21 (RAC1) activated kinase 2	sorbin and SH3 domain containing 3
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Postsynaptic Density Perinuclear Region Of Cytoplasm Glutamatergic Synapse	Nucleus Cytosol Cytoskeleton Focal Adhesion
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Protein Tyrosine Kinase Activator Activity Small GTPase Binding Identical Protein Binding Cadherin Binding Protein Serine Kinase Activity	Structural Constituent Of Cytoskeleton Protein Binding Vinculin Binding
	Biological Process	Stimulatory C-type Lectin Receptor Signaling Pathway Protein Phosphorylation Negative Regulation Of Protein Kinase Activity Apoptotic Process Signal Transduction Phosphorylation Peptidyl-serine Phosphorylation Adherens Junction Assembly Intracellular Signal Transduction Regulation Of Growth Negative Regulation Of Apoptotic Process Regulation Of MAPK Cascade Protein Autophosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Axonogenesis Regulation Of Cytoskeleton Organization Negative Regulation Of Stress Fiber Assembly Dendritic Spine Development Positive Regulation Of Protein Tyrosine Kinase Activity Bicellular Tight Junction Assembly Cellular Response To Organic Cyclic Compound Protein Localization To Cell-cell Junction Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis	Negative Regulation Of Transcription By RNA Polymerase II Actin Filament Organization Cell Adhesion Cell-substrate Adhesion Positive Regulation Of MAPK Cascade Positive Regulation Of Cytoskeleton Organization Positive Regulation Of Stress Fiber Assembly
Pathways		Nef and signal transduction Generation of second messenger molecules Regulation of PAK-2p34 activity by PS-GAP/RHG10 Regulation of activated PAK-2p34 by proteasome mediated degradation Stimulation of the cell death response by PAK-2p34 FCERI mediated MAPK activation FCERI mediated MAPK activation CD28 dependent Vav1 pathway Ephrin signaling Sema3A PAK dependent Axon repulsion Activation of RAC1 VEGFA-VEGFR2 Pathway Smooth Muscle Contraction VEGFR2 mediated vascular permeability CD209 (DC-SIGN) signaling RHO GTPases activate PAKs RHO GTPases activate PAKs MAPK6/MAPK4 signaling Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOQ GTPase cycle RHOH GTPase cycle RHOG GTPase cycle RHOJ GTPase cycle RHOU GTPase cycle RAC3 GTPase cycle RHOV GTPase cycle	Smooth Muscle Contraction
Drugs		Fostamatinib
Diseases
GWAS		Asthma ( 31959851) Atrial fibrillation ( 29892015) Eosinophil counts ( 32888494 27863252) Glucose homeostasis traits ( 25524916) Lymphocyte counts ( 32888494 27863252) Malaria ( 31844061) Mean corpuscular hemoglobin concentration ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494 27863252) Neutrophil count ( 32888494) Platelet count ( 32888494 27863252) Platelet distribution width ( 32888494) Plateletcrit ( 32888494 27863252) Red cell distribution width ( 32888494) Reticulocyte fraction of red cells ( 32888494) Sum eosinophil basophil counts ( 27863252) Total ventricular volume (Alzheimer's disease interaction) ( 21116278) White blood cell count ( 32888494 27863252)	Diastolic blood pressure ( 30224653) HIV-1 viral setpoint ( 20205591) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Parkinson's disease ( 28892059)
Interacting Genes		55 interacting genes: ABI1 ABI2 ABI3 ABL1 APP ARHGAP10 ARHGEF6 ARHGEF7 BRAF CASP3 CDC42 DOCK2 DST EIF4B EIF4G1 EP300 FYN GRB2 H4C6 HCK LCK LIMK1 LYN MAPK1 MAPK3 MKNK1 MYC MYL2 MYLK NCK1 NCK2 NPHP1 OGT PACSIN3 PPM1A RAC1 RAC2 RAF1 RHOJ RIOK3 RPS6 SH3GL2 SH3KBP1 SH3PXD2A SH3RF1 SH3RF3 SNX33 SNX9 SORBS1 SORBS2 SORBS3 SRC SYN1 VIM YES1	137 interacting genes: ABI2 ABL1 ADAM15 ADAMTSL4 ADAT3 AKIRIN2 AKT2 ANKS1A ARNT2 C1orf109 CATSPER1 CBFA2T2 CBLB CCDC102B CCDC120 CCDC187 CCDC57 CCDC6 CCHCR1 CCNH CCNL1 CDC23 CDKN2C CFAP206 CHERP COG4 CPEB2 CPNE1 CPNE2 CPNE8 CPSF7 CRACR2A DDX17 DDX6 DIP2A DLG5 DMRTB1 DVL2 DVL3 EFHC1 EFS EIF3H ENKD1 FAM214B FAM53C FASLG FBXL19 FLOT1 FNDC11 FXR1 GAS8 GEM GLRA1 GPANK1 GPKOW GYS1 HGS HNRNPF HNRNPK HNRNPUL1 IMP3 INPPL1 INSC IQUB KANK2 KIAA0408 KIAA1217 KIFC3 MAPK1 MAPK3 MKRN3 MYO15B NAB2 NAF1 NCK1 NCKIPSD NEK6 NFKBID NHSL2 NOTCH3 NRBP1 OIP5 OSGIN1 PAK2 PAK5 PHETA1 PHF1 PIBF1 PLEKHN1 PLOD3 PNMA5 POLE2 POLR1C PPFIA3 PPIL6 PPP1R18 PPP3CC QARS1 RAD51D RBMX RIN1 ROPN1 RUNX1T1 SAFB2 SAXO1 SCNM1 SETD5 SH2D4A SHANK3 SOCS7 SPG21 SRCIN1 SYNPO2L TBC1D22B TCEANC TEAD4 TEPSIN TNS2 TRIM23 TRIM27 TRIM41 TSC1 TSGA10 TSGA10IP TXLNA USP2 VARS2 VCL VPS37B VPS37C WIPF2 ZBED1 ZBTB25 ZBTB7B ZC2HC1C ZC4H2 ZNF414
Entrez ID		5062	10174
HPRD ID		05428	11535
Ensembl ID		ENSG00000180370	ENSG00000120896
Uniprot IDs		A8K5M4 Q13177	O60504
PDB IDs		3PCS	2CT3 2DLM 2NWM 2YUP
Enriched GO Terms of Interacting Partners?
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