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PAK2 and FYN
Number of citations of the paper that reports this interaction (PubMedID
16374509
)
43
Data Source:
HPRD
(in vitro)
PAK2
FYN
Description
p21 (RAC1) activated kinase 2
FYN proto-oncogene, Src family tyrosine kinase
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Cytosol
Plasma Membrane
Cell-cell Junction
Postsynaptic Density
Perinuclear Region Of Cytoplasm
Glutamatergic Synapse
Nucleus
Mitochondrion
Endosome
Cytosol
Actin Filament
Plasma Membrane
Postsynaptic Density
Dendrite
Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
Cell Body
Membrane Raft
Perinuclear Region Of Cytoplasm
Perinuclear Endoplasmic Reticulum
Glial Cell Projection
Schaffer Collateral - CA1 Synapse
Glutamatergic Synapse
Postsynaptic Density, Intracellular Component
Molecular Function
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Protein Kinase Binding
Protein Tyrosine Kinase Activator Activity
Small GTPase Binding
Identical Protein Binding
Cadherin Binding
Protein Serine Kinase Activity
Protein Tyrosine Kinase Activity
Transmembrane Receptor Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Signaling Receptor Binding
Protein Binding
ATP Binding
Phospholipase Activator Activity
Enzyme Binding
Type 5 Metabotropic Glutamate Receptor Binding
T Cell Receptor Binding
CD4 Receptor Binding
CD8 Receptor Binding
Identical Protein Binding
Alpha-tubulin Binding
Phospholipase Binding
Phosphatidylinositol 3-kinase Binding
Transmembrane Transporter Binding
Metal Ion Binding
Ephrin Receptor Binding
Tau Protein Binding
Tau-protein Kinase Activity
Peptide Hormone Receptor Binding
Growth Factor Receptor Binding
Scaffold Protein Binding
Disordered Domain Specific Binding
Biological Process
Stimulatory C-type Lectin Receptor Signaling Pathway
Protein Phosphorylation
Negative Regulation Of Protein Kinase Activity
Apoptotic Process
Signal Transduction
Phosphorylation
Peptidyl-serine Phosphorylation
Adherens Junction Assembly
Intracellular Signal Transduction
Regulation Of Growth
Negative Regulation Of Apoptotic Process
Regulation Of MAPK Cascade
Protein Autophosphorylation
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Regulation Of Axonogenesis
Regulation Of Cytoskeleton Organization
Negative Regulation Of Stress Fiber Assembly
Dendritic Spine Development
Positive Regulation Of Protein Tyrosine Kinase Activity
Bicellular Tight Junction Assembly
Cellular Response To Organic Cyclic Compound
Protein Localization To Cell-cell Junction
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis
Response To Singlet Oxygen
Neuron Migration
Stimulatory C-type Lectin Receptor Signaling Pathway
Adaptive Immune Response
Negative Regulation Of Inflammatory Response To Antigenic Stimulus
Heart Process
Protein Phosphorylation
Calcium Ion Transport
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Axon Guidance
Learning
Feeding Behavior
Regulation Of Cell Shape
Response To Xenobiotic Stimulus
Negative Regulation Of Gene Expression
Negative Regulation Of Hydrogen Peroxide Biosynthetic Process
Positive Regulation Of Neuron Projection Development
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Peptidyl-tyrosine Phosphorylation
Cell Differentiation
Forebrain Development
T Cell Costimulation
Negative Regulation Of Protein Ubiquitination
Intracellular Signal Transduction
Cellular Response To Platelet-derived Growth Factor Stimulus
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Negative Regulation Of Protein Catabolic Process
Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein
Response To Hydrogen Peroxide
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Negative Regulation Of Neuron Apoptotic Process
Innate Immune Response
Response To Ethanol
Protein Autophosphorylation
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Ephrin Receptor Signaling Pathway
Dendrite Morphogenesis
Regulation Of Peptidyl-tyrosine Phosphorylation
Activated T Cell Proliferation
Modulation Of Chemical Synaptic Transmission
T Cell Receptor Signaling Pathway
Leukocyte Migration
Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain
Cellular Response To Peptide Hormone Stimulus
Cellular Response To Transforming Growth Factor Beta Stimulus
Positive Regulation Of Protein Targeting To Membrane
Dendritic Spine Maintenance
Positive Regulation Of Protein Localization To Nucleus
Regulation Of Glutamate Receptor Signaling Pathway
Positive Regulation Of Neuron Death
Negative Regulation Of Dendritic Spine Maintenance
Negative Regulation Of Oxidative Stress-induced Cell Death
Response To Amyloid-beta
Cellular Response To Amyloid-beta
Cellular Response To L-glutamate
Cellular Response To Glycine
Positive Regulation Of Protein Localization To Membrane
Regulation Of Calcium Ion Import Across Plasma Membrane
Positive Regulation Of Cysteine-type Endopeptidase Activity
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways
Nef and signal transduction
Generation of second messenger molecules
Regulation of PAK-2p34 activity by PS-GAP/RHG10
Regulation of activated PAK-2p34 by proteasome mediated degradation
Stimulation of the cell death response by PAK-2p34
FCERI mediated MAPK activation
FCERI mediated MAPK activation
CD28 dependent Vav1 pathway
Ephrin signaling
Sema3A PAK dependent Axon repulsion
Activation of RAC1
VEGFA-VEGFR2 Pathway
Smooth Muscle Contraction
VEGFR2 mediated vascular permeability
CD209 (DC-SIGN) signaling
RHO GTPases activate PAKs
RHO GTPases activate PAKs
MAPK6/MAPK4 signaling
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
CDC42 GTPase cycle
RAC1 GTPase cycle
RAC2 GTPase cycle
RHOQ GTPase cycle
RHOH GTPase cycle
RHOG GTPase cycle
RHOJ GTPase cycle
RHOU GTPase cycle
RAC3 GTPase cycle
RHOV GTPase cycle
GPVI-mediated activation cascade
Signaling by ERBB2
PIP3 activates AKT signaling
Signaling by SCF-KIT
Signaling by SCF-KIT
Regulation of KIT signaling
Nef and signal transduction
Cell surface interactions at the vascular wall
FCGR activation
PECAM1 interactions
Constitutive Signaling by Aberrant PI3K in Cancer
DAP12 signaling
DAP12 signaling
EPH-Ephrin signaling
Role of LAT2/NTAL/LAB on calcium mobilization
Nephrin family interactions
Nephrin family interactions
NCAM signaling for neurite out-growth
NCAM signaling for neurite out-growth
CD28 co-stimulation
CD28 dependent PI3K/Akt signaling
CD28 dependent Vav1 pathway
CTLA4 inhibitory signaling
EPHB-mediated forward signaling
EPHB-mediated forward signaling
EPHA-mediated growth cone collapse
EPHA-mediated growth cone collapse
Ephrin signaling
Ephrin signaling
EPH-ephrin mediated repulsion of cells
Sema3A PAK dependent Axon repulsion
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
CRMPs in Sema3A signaling
CRMPs in Sema3A signaling
VEGFA-VEGFR2 Pathway
Dectin-2 family
CD209 (DC-SIGN) signaling
RAF/MAP kinase cascade
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Platelet Adhesion to exposed collagen
Reelin signalling pathway
Regulation of signaling by CBL
Regulation of signaling by CBL
FCGR3A-mediated IL10 synthesis
FCGR3A-mediated phagocytosis
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants
FLT3 signaling through SRC family kinases
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs
Fostamatinib
Dasatinib
Triglyme
Fostamatinib
Diseases
GWAS
Asthma (
31959851
)
Atrial fibrillation (
29892015
)
Eosinophil counts (
32888494
27863252
)
Glucose homeostasis traits (
25524916
)
Lymphocyte counts (
32888494
27863252
)
Malaria (
31844061
)
Mean corpuscular hemoglobin concentration (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Monocyte count (
32888494
27863252
)
Neutrophil count (
32888494
)
Platelet count (
32888494
27863252
)
Platelet distribution width (
32888494
)
Plateletcrit (
32888494
27863252
)
Red cell distribution width (
32888494
)
Reticulocyte fraction of red cells (
32888494
)
Sum eosinophil basophil counts (
27863252
)
Total ventricular volume (Alzheimer's disease interaction) (
21116278
)
White blood cell count (
32888494
27863252
)
Amyotrophic lateral sclerosis (sporadic) (
24529757
)
Anger (
24489884
)
Autoimmune thyroid disease (
32581359
)
Bipolar disorder (
31043756
)
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Height (
31562340
)
Inflammatory bowel disease (
28067908
23128233
)
Intraocular pressure (
29617998
)
Macular thickness (
30535121
)
NASH resolution in nonalcoholic steatohepatitis (
31832568
)
Parkinson's disease (
32201043
32310270
)
Parkinson's disease or first degree relation to individual with Parkinson's disease (
31701892
)
Schizophrenia (
28991256
30285260
)
Systolic blood pressure (
30578418
)
Ulcerative colitis (
28067908
)
Interacting Genes
55 interacting genes:
ABI1
ABI2
ABI3
ABL1
APP
ARHGAP10
ARHGEF6
ARHGEF7
BRAF
CASP3
CDC42
DOCK2
DST
EIF4B
EIF4G1
EP300
FYN
GRB2
H4C6
HCK
LCK
LIMK1
LYN
MAPK1
MAPK3
MKNK1
MYC
MYL2
MYLK
NCK1
NCK2
NPHP1
OGT
PACSIN3
PPM1A
RAC1
RAC2
RAF1
RHOJ
RIOK3
RPS6
SH3GL2
SH3KBP1
SH3PXD2A
SH3RF1
SH3RF3
SNX33
SNX9
SORBS1
SORBS2
SORBS3
SRC
SYN1
VIM
YES1
200 interacting genes:
ACP1
ADAM15
ADD2
ARHGAP32
ARHGAP33
ATXN1
BAG4
BCAR1
BCL3
BTK
C7orf25
C8orf33
CASP3
CASP8
CAV1
CBL
CBLB
CBLC
CD19
CD2
CD226
CD247
CD2AP
CD36
CD44
CD48
CD5
CD55
CD79A
CD79B
CDH1
CDK1
CDK5
CLTC
CMA1
CNN1
CNN3
CNTN1
CNTNAP1
CRK
CSF1R
CSF2RB
CSK
CTLA4
CTNNB1
CTNND2
DAG1
DLG4
DLGAP4
DOK1
DOK3
DOK4
DTX3
EFS
ENO1
EPHA3
EPHA4
EPHA8
EPHB3
ERRFI1
EVL
FAM90A1
FAS
FASLG
FCER2
FCGR2A
FLOT1
FLOT2
FLT1
FNBP4
FYB1
GAB3
GP6
GRAP
GRB10
GRB2
GRIN1
GRIN2A
GRIN2B
HDAC2
HNRNPK
HRAS
HSP90AA1
HTR6
IGHA1
IL1B
IL2RB
IL7R
IRS1
ITCH
ITGB4
ITK
ITPR1
JAK2
JUP
KDM1A
KDR
KHDRBS1
KIT
LAT
LCK
LCP2
MAG
MAP2
MAPT
MCAM
MED28
MEOX2
MS4A1
NCAM1
NEDD4
NEDD9
NMT1
NOS1AP
NPHS1
NR3C1
NTRK2
PAG1
PAK2
PDE4D
PDGFRB
PECAM1
PIK3R1
PIK3R2
PIK3R3
PLAUR
PLCG1
PLCG2
PLD2
PRKCD
PRKCE
PRKCH
PRKCQ
PRKCZ
PRMT6
PRMT8
PRRG4
PTK2
PTK2B
PTPN11
PTPN5
PTPRA
PTPRC
PTPRE
PTPRF
PTPRZ1
PXN
RACK1
RAF1
RPL10
RPS6KA3
RPS6KB2
SDC3
SH2B2
SH2D1A
SH3BP2
SHC1
SIT1
SKAP1
SKAP2
SLAMF1
SNCA
SOCS1
SOS1
SPHK1
SPHK2
SPN
STAT1
STAT3
SUV39H1
SYK
TAMALIN
TCAP
THY1
TNF
TNK2
TNNT1
TOM1L1
TRAF6
TRAT1
TRIM55
TRIM63
TRPC6
TRPV4
TUBA1B
TUBA3C
TUBA4A
TXK
TYK2
TYRO3
UHRF2
UNC119
VAV1
VAV2
WAS
WASF1
WASF2
WBP11
YTHDC1
ZAP70
Entrez ID
5062
2534
HPRD ID
05428
00655
Ensembl ID
ENSG00000180370
ENSG00000010810
Uniprot IDs
A8K5M4
Q13177
P06241
PDB IDs
3PCS
1A0N
1AOT
1AOU
1AVZ
1AZG
1EFN
1FYN
1G83
1M27
1NYF
1NYG
1SHF
1ZBJ
2DQ7
2MQI
2MRJ
2MRK
3H0F
3H0H
3H0I
3UA6
3UA7
4D8D
4EIK
4U17
4U1P
4ZNX
5ZAU
6EDF
6IPY
6IPZ
Enriched GO Terms of Interacting Partners
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