SORBS3 and DLG5

Number of citations of the paper that reports this interaction (PubMedID 12657639)
15

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		SORBS3	DLG5
Description		sorbin and SH3 domain containing 3	discs large MAGUK scaffold protein 5
Image
GO Annotations	Cellular Component	Nucleus Cytosol Cytoskeleton Focal Adhesion	Cytoplasm Plasma Membrane Adherens Junction Postsynaptic Density Cell Junction Ciliary Basal Body
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding Vinculin Binding	Protein Binding Beta-catenin Binding Cytoskeletal Protein Binding Signaling Receptor Complex Adaptor Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Actin Filament Organization Cell Adhesion Cell-substrate Adhesion Positive Regulation Of MAPK Cascade Positive Regulation Of Cytoskeleton Organization Positive Regulation Of Stress Fiber Assembly	Epithelial To Mesenchymal Transition Signal Transduction Negative Regulation Of Cell Population Proliferation Maintenance Of Cell Polarity Negative Regulation Of Cell Migration Polarized Epithelial Cell Differentiation Midbrain Development Negative Regulation Of Hippo Signaling Positive Regulation Of Hippo Signaling Intracellular Signal Transduction Negative Regulation Of T Cell Proliferation Regulation Of Apoptotic Process Apical Protein Localization Zonula Adherens Assembly Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Positive Regulation Of Smoothened Signaling Pathway Positive Regulation Of Synapse Assembly Epithelial Tube Branching Involved In Lung Morphogenesis Positive Regulation Of Dendritic Spine Development Protein-containing Complex Assembly Protein Localization To Adherens Junction Metanephric Collecting Duct Development Cell-cell Adhesion
Pathways		Smooth Muscle Contraction	RHOU GTPase cycle RHOV GTPase cycle RND3 GTPase cycle RND2 GTPase cycle RND1 GTPase cycle
Drugs
Diseases
GWAS		Diastolic blood pressure ( 30224653) HIV-1 viral setpoint ( 20205591) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Parkinson's disease ( 28892059)	Alanine aminotransferase levels ( 33547301 34315874 33339817) Alanine transaminase levels ( 29403010) Aspartate aminotransferase levels ( 33547301 34315874) Gamma glutamyl transferase levels ( 29403010 33339817) Liver enzyme levels (alanine transaminase) ( 33972514) Liver enzyme levels (alkaline phosphatase) ( 33972514) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514 22001757) Macular thickness ( 30535121) Obesity-related traits ( 23251661) Retinal detachment or retinal break ( 31816047) Serum alkaline phosphatase levels ( 33547301)
Interacting Genes		137 interacting genes: ABI2 ABL1 ADAM15 ADAMTSL4 ADAT3 AKIRIN2 AKT2 ANKS1A ARNT2 C1orf109 CATSPER1 CBFA2T2 CBLB CCDC102B CCDC120 CCDC187 CCDC57 CCDC6 CCHCR1 CCNH CCNL1 CDC23 CDKN2C CFAP206 CHERP COG4 CPEB2 CPNE1 CPNE2 CPNE8 CPSF7 CRACR2A DDX17 DDX6 DIP2A DLG5 DMRTB1 DVL2 DVL3 EFHC1 EFS EIF3H ENKD1 FAM214B FAM53C FASLG FBXL19 FLOT1 FNDC11 FXR1 GAS8 GEM GLRA1 GPANK1 GPKOW GYS1 HGS HNRNPF HNRNPK HNRNPUL1 IMP3 INPPL1 INSC IQUB KANK2 KIAA0408 KIAA1217 KIFC3 MAPK1 MAPK3 MKRN3 MYO15B NAB2 NAF1 NCK1 NCKIPSD NEK6 NFKBID NHSL2 NOTCH3 NRBP1 OIP5 OSGIN1 PAK2 PAK5 PHETA1 PHF1 PIBF1 PLEKHN1 PLOD3 PNMA5 POLE2 POLR1C PPFIA3 PPIL6 PPP1R18 PPP3CC QARS1 RAD51D RBMX RIN1 ROPN1 RUNX1T1 SAFB2 SAXO1 SCNM1 SETD5 SH2D4A SHANK3 SOCS7 SPG21 SRCIN1 SYNPO2L TBC1D22B TCEANC TEAD4 TEPSIN TNS2 TRIM23 TRIM27 TRIM41 TSC1 TSGA10 TSGA10IP TXLNA USP2 VARS2 VCL VPS37B VPS37C WIPF2 ZBED1 ZBTB25 ZBTB7B ZC2HC1C ZC4H2 ZNF414	8 interacting genes: ABCA1 BTBD10 CD81 CTNNB1 DLST PFN1 SORBS3 TERF1
Entrez ID		10174	9231
HPRD ID		11535	04972
Ensembl ID		ENSG00000120896	ENSG00000151208
Uniprot IDs		O60504	Q8TDM6
PDB IDs		2CT3 2DLM 2NWM 2YUP	1UIT
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?