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PAK1 and DYNLL2
Number of citations of the paper that reports this interaction (PubMedID
21988832
)
87
Data Source:
BioGRID
(two hybrid)
PAK1
DYNLL2
Description
p21 (RAC1) activated kinase 1
dynein light chain LC8-type 2
Image
GO Annotations
Cellular Component
Ruffle
Nucleoplasm
Chromosome
Cytoplasm
Microtubule Organizing Center
Cytosol
Actin Filament
Plasma Membrane
Cell-cell Junction
Focal Adhesion
Intercalated Disc
Z Disc
Lamellipodium
Axon
Dendrite
Nuclear Membrane
Ruffle Membrane
Protein-containing Complex
Nucleus
Centrosome
Cytosol
Cytoplasmic Dynein Complex
Microtubule
Plasma Membrane
Cilium
Postsynaptic Density
Membrane
Dynein Complex
Myosin V Complex
Ciliary Tip
9+0 Non-motile Cilium
Postsynapse
Glutamatergic Synapse
Molecular Function
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
Collagen Binding
ATP Binding
Protein Kinase Binding
Small GTPase Binding
Gamma-tubulin Binding
Protein Serine Kinase Activity
Protein Binding
Identical Protein Binding
Protein-containing Complex Binding
Dynein Intermediate Chain Binding
Dynein Light Intermediate Chain Binding
Scaffold Protein Binding
Biological Process
MAPK Cascade
Response To Hypoxia
Positive Regulation Of Protein Phosphorylation
Stimulatory C-type Lectin Receptor Signaling Pathway
Chromatin Remodeling
Protein Phosphorylation
Exocytosis
Apoptotic Process
Cellular Response To DNA Damage Stimulus
Positive Regulation Of Cell Population Proliferation
Positive Regulation Of Fibroblast Migration
Phosphorylation
Cell Migration
Cerebellum Development
Establishment Of Cell Polarity
Positive Regulation Of Cell Migration
Positive Regulation Of Microtubule Polymerization
Actin Cytoskeleton Reorganization
Cellular Response To Insulin Stimulus
Regulation Of Actin Cytoskeleton Organization
Positive Regulation Of Peptidyl-serine Phosphorylation
Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway
Intracellular Signal Transduction
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Wound Healing
Regulation Of MAPK Cascade
Positive Regulation Of JUN Kinase Activity
Positive Regulation Of Axon Extension
Positive Regulation Of Insulin Receptor Signaling Pathway
Protein Autophosphorylation
Hepatocyte Growth Factor Receptor Signaling Pathway
Ephrin Receptor Signaling Pathway
Branching Morphogenesis Of An Epithelial Tube
Neuron Projection Morphogenesis
Regulation Of Axonogenesis
Positive Regulation Of Stress Fiber Assembly
Negative Regulation Of Cell Proliferation Involved In Contact Inhibition
Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development
Positive Regulation Of Microtubule Nucleation
Positive Regulation Of Protein Targeting To Membrane
Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration
Microtubule-based Process
Cilium Assembly
Pathways
Generation of second messenger molecules
Regulation of actin dynamics for phagocytic cup formation
FCERI mediated MAPK activation
FCERI mediated MAPK activation
DSCAM interactions
CD28 dependent Vav1 pathway
EPHB-mediated forward signaling
Ephrin signaling
Sema3A PAK dependent Axon repulsion
Activation of RAC1
Signal transduction by L1
Smooth Muscle Contraction
VEGFR2 mediated vascular permeability
CD209 (DC-SIGN) signaling
RHO GTPases activate PKNs
RHO GTPases Activate ROCKs
RHO GTPases activate PAKs
RHO GTPases activate PAKs
MAPK6/MAPK4 signaling
G beta:gamma signalling through CDC42
CDC42 GTPase cycle
RAC1 GTPase cycle
RAC2 GTPase cycle
RHOQ GTPase cycle
RHOH GTPase cycle
RHOJ GTPase cycle
RHOU GTPase cycle
RAC3 GTPase cycle
RHOV GTPase cycle
Activation of BMF and translocation to mitochondria
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Macroautophagy
MHC class II antigen presentation
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand
Intraflagellar transport
RHO GTPases Activate Formins
COPI-mediated anterograde transport
COPI-independent Golgi-to-ER retrograde traffic
Mitotic Prometaphase
HCMV Early Events
Aggrephagy
Aggrephagy
EML4 and NUDC in mitotic spindle formation
Drugs
Fostamatinib
Diseases
GWAS
Post bronchodilator FEV1/FVC ratio (
26634245
)
Tourette syndrome (
30818990
)
Blood protein levels (
30072576
)
Interacting Genes
85 interacting genes:
ABI3
ACTA1
ACVR1
AKT1
APP
ARHGEF2
ARHGEF6
ARHGEF7
ARPC1B
BAD
BAIAP2
BMPR1B
BMX
BRSK1
CASP1
CDC42
CDK11B
CDK5
CDK5R1
CHORDC1
COL1A1
CPLANE1
CSNK2A1
CSNK2A2
DSCAM
DYNLL1
DYNLL2
DYRK1B
EGFR
ELF3
ERBB2
ESR1
FLNA
FOXL2
FOXO1
FRS2
GIT2
GRB2
H3C1
H4C1
HACE1
HGS
HSP90AA1
LIMK1
MAP2K1
MAP3K1
MAPK1
MBP
MYLK
MYNN
MYO6
NCK1
NCK2
NF2
OXSR1
PAK1IP1
PDPK1
PLCG1
PPM1A
PPM1F
PPP1CA
PPP2CA
PRKCD
PXN
RAC1
RAF1
RHOJ
RHOU
SHC1
SMAD1
SMAD2
SMAD4
SMURF1
SORBS2
SYN1
TGFBR1
TGFBR2
TGM2
YWHAG
YWHAZ
ZBTB18
ZC3H7A
ZNF418
ZNF823
ZNF83
43 interacting genes:
BCL2L11
BMF
C12orf40
C14orf119
C17orf67
CHMP5
DLGAP1
DNAL4
DPPA3
DYNC1I1
EWSR1
F13A1
FAM117B
GABARAPL2
GPHN
GPRIN2
HDAC6
HMBOX1
HOMER3
HSF5
IHO1
KANK2
KIF2B
MEOX2
MORN3
MSI2
MYO5A
OTUD6A
PAK1
PKIA
PKIG
PRKD3
RASGRP3
SECISBP2L
SKAP1
SMCP
SPAG8
STXBP4
THAP10
TLK1
TPPP
XIAP
ZAR1
Entrez ID
5058
140735
HPRD ID
03995
06489
Ensembl ID
ENSG00000149269
ENSG00000264364
Uniprot IDs
A0A024R5P0
Q13153
Q96FJ2
PDB IDs
1F3M
1YHV
1YHW
1ZSG
2HY8
2QME
3DVP
3FXZ
3FY0
3Q4Z
3Q52
3Q53
4DAW
4EQC
4O0R
4O0T
4P90
4ZJI
4ZJJ
4ZLO
4ZY4
4ZY5
4ZY6
5DEW
5DEY
5DFP
5IME
5KBQ
5KBR
6B16
2XQQ
3P8M
4D07
Enriched GO Terms of Interacting Partners
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