PRDX1 and SESN2

Number of citations of the paper that reports this interaction (PubMedID 15105503)
290

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		PRDX1	SESN2
Description		peroxiredoxin 1	sestrin 2
Image
GO Annotations	Cellular Component	Extracellular Space Nucleus Cytoplasm Cytosol Melanosome Extracellular Exosome	Nucleus Cytoplasm Mitochondrion Cytosol Atg1/ULK1 Kinase Complex
	Molecular Function	RNA Binding Peroxidase Activity Protein Binding Thioredoxin Peroxidase Activity Identical Protein Binding Cadherin Binding	GDP-dissociation Inhibitor Activity Protein Binding Oxidoreductase Activity, Acting On Peroxide As Acceptor Sulfiredoxin Activity Protein-containing Complex Binding Leucine Binding
	Biological Process	Skeletal System Development Retina Homeostasis Response To Oxidative Stress Cell Population Proliferation Removal Of Superoxide Radicals Natural Killer Cell Activation Regulation Of Stress-activated MAPK Cascade Cellular Response To Stress Erythrocyte Homeostasis Natural Killer Cell Mediated Cytotoxicity Hydrogen Peroxide Catabolic Process Leukocyte Activation Cell Redox Homeostasis Regulation Of NIK/NF-kappaB Signaling	Regulation Of Protein Phosphorylation Regulation Of Gluconeogenesis Fatty Acid Beta-oxidation Response To Glucose Positive Regulation Of Macroautophagy Negative Regulation Of Cell Growth DNA Damage Response, Signal Transduction By P53 Class Mediator Mitochondrial DNA Metabolic Process Response To Insulin Cellular Response To Amino Acid Starvation Cellular Response To Oxidative Stress Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress Cellular Response To Glucose Starvation Glucose Homeostasis Protein Kinase B Signaling Glucose Import Triglyceride Homeostasis Cellular Response To Amino Acid Stimulus Cellular Response To Leucine Reactive Oxygen Species Metabolic Process Cellular Oxidant Detoxification Positive Regulation Of Protein Localization To Nucleus Regulation Of Response To Reactive Oxygen Species Negative Regulation Of Translation In Response To Endoplasmic Reticulum Stress Negative Regulation Of TORC1 Signaling Positive Regulation Of Lipophagy Cellular Response To Leucine Starvation Regulation Of CAMP-dependent Protein Kinase Activity
Pathways		Detoxification of Reactive Oxygen Species TP53 Regulates Metabolic Genes Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	TP53 Regulates Metabolic Genes Amino acids regulate mTORC1
Drugs		Zinc Copper Artenimol Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Blood protein levels ( 28240269) Body mass index ( 26426971) Hemoglobin ( 32888494)	Aspartate aminotransferase levels ( 33547301) Serum uric acid levels ( 30993211) Urate levels ( 31578528)
Interacting Genes		30 interacting genes: ABL1 ADH5 ADRB2 AXIN2 BTRC CALM1 CCR4 CLEC4G EGFR EXOSC3 GAPDH IRF3 LUC7L MTRNR2L1 MYC MYD88 PPP2R1A PPP2R1B PRDX4 PTEN PTGER4 SESN1 SESN2 SH2D1B SMARCD1 SNCA TERF1 UBE3A VHL YWHAQ	3 interacting genes: MDM2 PRDX1 RNF186
Entrez ID		5052	83667
HPRD ID		01458	06378
Ensembl ID		ENSG00000117450	ENSG00000130766
Uniprot IDs		A0A384NPQ2 Q06830	P58004
PDB IDs		2RII 3HY2 4XCS	5CUF 5DJ4 5T0N 6N0M
Enriched GO Terms of Interacting Partners?
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