PRDX1 and ADH5

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		PRDX1	ADH5
Description		peroxiredoxin 1	alcohol dehydrogenase 5 (class III), chi polypeptide
Image
GO Annotations	Cellular Component	Extracellular Space Nucleus Cytoplasm Cytosol Melanosome Extracellular Exosome	Mitochondrion Cytosol Extracellular Exosome
	Molecular Function	RNA Binding Peroxidase Activity Protein Binding Thioredoxin Peroxidase Activity Identical Protein Binding Cadherin Binding	Alcohol Dehydrogenase Activity, Zinc-dependent Fatty Acid Binding Zinc Ion Binding Electron Transfer Activity Formaldehyde Dehydrogenase Activity Identical Protein Binding S-(hydroxymethyl)glutathione Dehydrogenase Activity S-(hydroxymethyl)glutathione Dehydrogenase NADP Activity S-(hydroxymethyl)glutathione Dehydrogenase NAD Activity
	Biological Process	Skeletal System Development Retina Homeostasis Response To Oxidative Stress Cell Population Proliferation Removal Of Superoxide Radicals Natural Killer Cell Activation Regulation Of Stress-activated MAPK Cascade Cellular Response To Stress Erythrocyte Homeostasis Natural Killer Cell Mediated Cytotoxicity Hydrogen Peroxide Catabolic Process Leukocyte Activation Cell Redox Homeostasis Regulation Of NIK/NF-kappaB Signaling	Retinoid Metabolic Process Respiratory System Process Ethanol Oxidation Fatty Acid Omega-oxidation Peptidyl-cysteine S-nitrosylation Electron Transport Chain Response To Lipopolysaccharide Positive Regulation Of Blood Pressure Formaldehyde Catabolic Process Response To Nitrosative Stress Response To Redox State
Pathways		Detoxification of Reactive Oxygen Species TP53 Regulates Metabolic Genes Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	Ethanol oxidation
Drugs		Zinc Copper Artenimol Zinc acetate Zinc chloride Zinc sulfate, unspecified form	NADH Lauric acid 12-Hydroxydodecanoic Acid S-Hydroxymethyl Glutathione
Diseases
GWAS		Blood protein levels ( 28240269) Body mass index ( 26426971) Hemoglobin ( 32888494)	Alcohol consumption ( 28937693) Alcohol consumption in current drinkers ( 28937693) Alcohol dependence ( 23456092) Blood protein levels ( 30072576) HDL cholesterol ( 24097068 25961943) HDL cholesterol levels ( 28334899) Obesity-related traits ( 23251661) Plateletcrit ( 32888494) Regular attendance at a pub or social club ( 29970889)
Interacting Genes		30 interacting genes: ABL1 ADH5 ADRB2 AXIN2 BTRC CALM1 CCR4 CLEC4G EGFR EXOSC3 GAPDH IRF3 LUC7L MTRNR2L1 MYC MYD88 PPP2R1A PPP2R1B PRDX4 PTEN PTGER4 SESN1 SESN2 SH2D1B SMARCD1 SNCA TERF1 UBE3A VHL YWHAQ	10 interacting genes: APP ARNT CHD3 CSNK2B ESRRA KEAP1 PRDX1 SLC66A2 SNTA1 VTN
Entrez ID		5052	128
HPRD ID		01458	00064
Ensembl ID		ENSG00000117450	ENSG00000197894
Uniprot IDs		A0A384NPQ2 Q06830	P11766 Q6IRT1
PDB IDs		2RII 3HY2 4XCS	1M6H 1M6W 1MA0 1MC5 1MP0 1TEH 2FZE 2FZW 3QJ5
Enriched GO Terms of Interacting Partners?
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