SESN2

Description		sestrin 2
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GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Cytosol Atg1/ULK1 Kinase Complex
	Molecular Function	GDP-dissociation Inhibitor Activity Protein Binding Oxidoreductase Activity, Acting On Peroxide As Acceptor Sulfiredoxin Activity Protein-containing Complex Binding Leucine Binding
	Biological Process	Regulation Of Protein Phosphorylation Regulation Of Gluconeogenesis Fatty Acid Beta-oxidation Response To Glucose Positive Regulation Of Macroautophagy Negative Regulation Of Cell Growth DNA Damage Response, Signal Transduction By P53 Class Mediator Mitochondrial DNA Metabolic Process Response To Insulin Cellular Response To Amino Acid Starvation Cellular Response To Oxidative Stress Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress Cellular Response To Glucose Starvation Glucose Homeostasis Protein Kinase B Signaling Glucose Import Triglyceride Homeostasis Cellular Response To Amino Acid Stimulus Cellular Response To Leucine Reactive Oxygen Species Metabolic Process Cellular Oxidant Detoxification Positive Regulation Of Protein Localization To Nucleus Regulation Of Response To Reactive Oxygen Species Negative Regulation Of Translation In Response To Endoplasmic Reticulum Stress Negative Regulation Of TORC1 Signaling Positive Regulation Of Lipophagy Cellular Response To Leucine Starvation Regulation Of CAMP-dependent Protein Kinase Activity
Pathways		TP53 Regulates Metabolic Genes Amino acids regulate mTORC1
Drugs
Diseases
GWAS		Aspartate aminotransferase levels ( 33547301) Serum uric acid levels ( 30993211) Urate levels ( 31578528)
Interacting Genes		3 interacting genes: MDM2 PRDX1 RNF186
Entrez ID		83667
HPRD ID		06378
Ensembl ID		ENSG00000130766
Uniprot IDs		P58004
PDB IDs		5CUF 5DJ4 5T0N 6N0M
Enriched GO Terms of Interacting Partners?
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