NPR1 and NPPC

Number of citations of the paper that reports this interaction (PubMedID 1660465)
23

Data Source:
BioGRID (pull down)

		NPR1	NPPC
Description		natriuretic peptide receptor 1	natriuretic peptide C
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane Receptor Complex	Extracellular Region Extracellular Space Secretory Granule Protein-containing Complex
	Molecular Function	Peptide Receptor Activity Guanylate Cyclase Activity Protein Kinase Activity ATP Binding GTP Binding G Protein-coupled Peptide Receptor Activity Natriuretic Peptide Receptor Activity Peptide Hormone Binding Hormone Binding	Signaling Receptor Binding Hormone Activity Hormone Receptor Binding
	Biological Process	CGMP Biosynthetic Process Protein Phosphorylation Signal Transduction Cell Surface Receptor Signaling Pathway Receptor Guanylyl Cyclase Signaling Pathway G Protein-coupled Receptor Signaling Pathway Body Fluid Secretion Regulation Of Blood Pressure Positive Regulation Of CGMP-mediated Signaling Negative Regulation Of Angiogenesis CGMP-mediated Signaling Negative Regulation Of Cell Growth Positive Regulation Of Urine Volume Positive Regulation Of Renal Sodium Excretion Dopamine Metabolic Process Regulation Of Vascular Permeability Negative Regulation Of Smooth Muscle Cell Proliferation Blood Vessel Diameter Maintenance	Ossification Response To Hypoxia Growth Plate Cartilage Chondrocyte Differentiation Growth Plate Cartilage Chondrocyte Proliferation CGMP Biosynthetic Process Protein Folding Receptor Guanylyl Cyclase Signaling Pathway Negative Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Post-embryonic Development Positive Regulation Of CGMP-mediated Signaling CGMP-mediated Signaling Reproductive Process Negative Regulation Of Collagen Biosynthetic Process Regulation Of Multicellular Organism Growth Response To Ethanol Positive Regulation Of Osteoblast Differentiation Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Meiotic Cell Cycle Negative Regulation Of Oocyte Maturation Negative Regulation Of DNA Biosynthetic Process
Pathways		Physiological factors	Physiological factors
Drugs		Nitroprusside Nitroglycerin Isosorbide dinitrate Amyl Nitrite Erythrityl tetranitrate Nesiritide Ularitide
Diseases
GWAS		Mean arterial pressure ( 27618448) Systolic blood pressure ( 27618448)	Height ( 20881960 25282103 25429064 19570815 18391951) Hip circumference adjusted for BMI ( 34021172) Refractive error ( 32231278) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for body mass index ( 34021172 28448500)
Interacting Genes		7 interacting genes: ATF7IP MTDH NPPA NPPB NPPC PRKG1 UBE2D2	4 interacting genes: MME NPR1 NPR2 NPR3
Entrez ID		4881	4880
HPRD ID		00165	08975
Ensembl ID		ENSG00000169418	ENSG00000163273
Uniprot IDs		A0A140VJE6 P16066	E5LCN7 P23582
PDB IDs			1JDP
Enriched GO Terms of Interacting Partners?
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