NPPC and NPR3

Number of citations of the paper that reports this interaction (PubMedID 1672777)
90

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		NPPC	NPR3
Description		natriuretic peptide C	natriuretic peptide receptor 3
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Secretory Granule Protein-containing Complex	Integral Component Of Plasma Membrane Protein-containing Complex Extracellular Exosome
	Molecular Function	Signaling Receptor Binding Hormone Activity Hormone Receptor Binding	Protein Binding G Protein-coupled Peptide Receptor Activity Natriuretic Peptide Receptor Activity Peptide Hormone Binding Chloride Ion Binding Peptide Binding Hormone Binding Protein Homodimerization Activity
	Biological Process	Ossification Response To Hypoxia Growth Plate Cartilage Chondrocyte Differentiation Growth Plate Cartilage Chondrocyte Proliferation CGMP Biosynthetic Process Protein Folding Receptor Guanylyl Cyclase Signaling Pathway Negative Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Post-embryonic Development Positive Regulation Of CGMP-mediated Signaling CGMP-mediated Signaling Reproductive Process Negative Regulation Of Collagen Biosynthetic Process Regulation Of Multicellular Organism Growth Response To Ethanol Positive Regulation Of Osteoblast Differentiation Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Meiotic Cell Cycle Negative Regulation Of Oocyte Maturation Negative Regulation Of DNA Biosynthetic Process	Skeletal System Development Osteoclast Proliferation Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Blood Pressure Pancreatic Juice Secretion Regulation Of Osteoblast Proliferation Positive Regulation Of Urine Volume Vasodilation Phosphatidylinositol-mediated Signaling Negative Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Nitric-oxide Synthase Activity Negative Regulation Of Cold-induced Thermogenesis
Pathways		Physiological factors
Drugs			Nesiritide
Diseases
GWAS		Height ( 20881960 25282103 25429064 19570815 18391951) Hip circumference adjusted for BMI ( 34021172) Refractive error ( 32231278) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for body mass index ( 34021172 28448500)	Blood pressure ( 24954895 21572416 21909110) Diastolic blood pressure ( 26390057 27841878 21909115 28739976 27618452) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Height ( 28552196 20881960 25282103 19343178 23563607 31562340 28270201 19570815) Hip circumference adjusted for BMI ( 34021172 25673412) Hypertension ( 31879980 21909115) Mean arterial pressure ( 26390057 29403010 30487518) Mean arterial pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Ovarian reserve ( 22116950) Pulse pressure ( 27841878 28739976 30578418) Pulse pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962) Symptoms in placebo-treated COVID-19 outpatients at risk of severe disease (time to remission) ( 34035401) Systolic blood pressure ( 26390057 28135244 27841878 21909115 29403010 28739976 27618447 27618452 30578418) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for body mass index ( 34021172 28448500) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		4 interacting genes: MME NPR1 NPR2 NPR3	6 interacting genes: NFKBIE NPPA NPPB NPPC NSD1 SLC30A9
Entrez ID		4880	4883
HPRD ID		08975	00167
Ensembl ID		ENSG00000163273	ENSG00000113389
Uniprot IDs		E5LCN7 P23582	A8K4A5 P17342 Q60I31
PDB IDs		1JDP	1JDN 1JDP 1YK0 1YK1
Enriched GO Terms of Interacting Partners?
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