NPPC and NPR2

Number of citations of the paper that reports this interaction (PubMedID 1672777)
90

Data Source:
BioGRID (pull down)
HPRD (in vivo)

		NPPC	NPR2
Description		natriuretic peptide C	natriuretic peptide receptor 2
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Secretory Granule Protein-containing Complex	Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Signaling Receptor Binding Hormone Activity Hormone Receptor Binding	Peptide Receptor Activity Guanylate Cyclase Activity Protein Kinase Activity Protein Binding ATP Binding GTP Binding Natriuretic Peptide Receptor Activity Peptide Hormone Binding Hormone Binding Identical Protein Binding
	Biological Process	Ossification Response To Hypoxia Growth Plate Cartilage Chondrocyte Differentiation Growth Plate Cartilage Chondrocyte Proliferation CGMP Biosynthetic Process Protein Folding Receptor Guanylyl Cyclase Signaling Pathway Negative Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Post-embryonic Development Positive Regulation Of CGMP-mediated Signaling CGMP-mediated Signaling Reproductive Process Negative Regulation Of Collagen Biosynthetic Process Regulation Of Multicellular Organism Growth Response To Ethanol Positive Regulation Of Osteoblast Differentiation Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Meiotic Cell Cycle Negative Regulation Of Oocyte Maturation Negative Regulation Of DNA Biosynthetic Process	Ossification CGMP Biosynthetic Process Protein Phosphorylation Signal Transduction Receptor Guanylyl Cyclase Signaling Pathway Regulation Of Blood Pressure Positive Regulation Of CGMP-mediated Signaling CGMP-mediated Signaling Reproductive Process Negative Regulation Of Meiotic Cell Cycle Bone Development Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus Negative Regulation Of Oocyte Maturation
Pathways		Physiological factors	Physiological factors
Drugs			Erythrityl tetranitrate Nesiritide
Diseases
GWAS		Height ( 20881960 25282103 25429064 19570815 18391951) Hip circumference adjusted for BMI ( 34021172) Refractive error ( 32231278) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for body mass index ( 34021172 28448500)	Blood protein levels ( 28240269) Brain morphology (MOSTest) ( 32665545) Heel bone mineral density ( 30598549) Height ( 31562340)
Interacting Genes		4 interacting genes: MME NPR1 NPR2 NPR3	4 interacting genes: DNAI1 NPPA NPPB NPPC
Entrez ID		4880	4882
HPRD ID		08975	00166
Ensembl ID		ENSG00000163273	ENSG00000159899
Uniprot IDs		E5LCN7 P23582	P20594
PDB IDs		1JDP
Enriched GO Terms of Interacting Partners?
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