NPR3 and NFKBIE

		NPR3	NFKBIE
Description		natriuretic peptide receptor 3	NFKB inhibitor epsilon
Image			No pdb structure
GO Annotations	Cellular Component	Integral Component Of Plasma Membrane Protein-containing Complex Extracellular Exosome	Fibrillar Center Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Protein Binding G Protein-coupled Peptide Receptor Activity Natriuretic Peptide Receptor Activity Peptide Hormone Binding Chloride Ion Binding Peptide Binding Hormone Binding Protein Homodimerization Activity	Protein Binding
	Biological Process	Skeletal System Development Osteoclast Proliferation Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Blood Pressure Pancreatic Juice Secretion Regulation Of Osteoblast Proliferation Positive Regulation Of Urine Volume Vasodilation Phosphatidylinositol-mediated Signaling Negative Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Nitric-oxide Synthase Activity Negative Regulation Of Cold-induced Thermogenesis	Cytoplasmic Sequestering Of Transcription Factor
Pathways			Activation of NF-kappaB in B cells
Drugs		Nesiritide
Diseases
GWAS		Blood pressure ( 24954895 21572416 21909110) Diastolic blood pressure ( 26390057 27841878 21909115 28739976 27618452) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Height ( 28552196 20881960 25282103 19343178 23563607 31562340 28270201 19570815) Hip circumference adjusted for BMI ( 34021172 25673412) Hypertension ( 31879980 21909115) Mean arterial pressure ( 26390057 29403010 30487518) Mean arterial pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Ovarian reserve ( 22116950) Pulse pressure ( 27841878 28739976 30578418) Pulse pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962) Symptoms in placebo-treated COVID-19 outpatients at risk of severe disease (time to remission) ( 34035401) Systolic blood pressure ( 26390057 28135244 27841878 21909115 29403010 28739976 27618447 27618452 30578418) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for body mass index ( 34021172 28448500) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Monocyte count ( 32888494 27863252) Monocyte percentage of white cells ( 32888494 27863252) Rheumatoid arthritis ( 32723749 30423114 22446963 23028356 24390342)
Interacting Genes		6 interacting genes: NFKBIE NPPA NPPB NPPC NSD1 SLC30A9	21 interacting genes: ANKHD1 BYSL C1QBP COG7 CUL1 GUCA1B HDAC4 HDAC5 IL1A JUP KBTBD7 NCOR2 NFKB1 NFKB2 NPR3 PEX6 POLH PPP6C REL RELA SKP1
Entrez ID		4883	4794
HPRD ID		00167	05181
Ensembl ID		ENSG00000113389	ENSG00000146232
Uniprot IDs		A8K4A5 P17342 Q60I31	A0A024RD24 O00221 Q7LC14 Q96F31
PDB IDs		1JDN 1JDP 1YK0 1YK1
Enriched GO Terms of Interacting Partners?
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