NFE2 and ELF5

Number of citations of the paper that reports this interaction (PubMedID 20211142)
361

Data Source:
BioGRID (two hybrid)

		NFE2	ELF5
Description		nuclear factor, erythroid 2	E74 like ETS transcription factor 5
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm PML Body Protein-DNA Complex	Chromatin Nucleus
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA Binding DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding Sequence-specific DNA Binding Protein N-terminus Binding WW Domain Binding Sequence-specific Double-stranded DNA Binding	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Nucleosome Disassembly Regulation Of Transcription By RNA Polymerase II Multicellular Organism Development Hemostasis Positive Regulation Of Transcription, DNA-templated	Regulation Of Transcription By RNA Polymerase II Cell Differentiation
Pathways		RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Factors involved in megakaryocyte development and platelet production Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Chronotype ( 30696823) High light scatter reticulocyte count ( 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Mean platelet volume ( 22139419 24026423) Mean spheric corpuscular volume ( 32888494) Meat-related diet ( 32066663) Platelet count ( 29403010 32888494 27863252) Platelet distribution width ( 32888494) Plateletcrit ( 27863252) Red cell distribution width ( 28957414) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	β2-Glycoprotein I (β2-GPI) plasma levels ( 23279374) Blood protein levels ( 28240269) Metabolite levels ( 23823483)
Interacting Genes		22 interacting genes: ATF4 BTRC CREBBP ELF5 HMGN1 ITCH KAT2B MAFF MAFG MAFK MAPK8 NEDD4 NFE2L2 NFE2L3 PEX14 PHYHIP PRIM1 SCAND1 SSX5 TXN WWP1 YAP1	10 interacting genes: ACTR2 FRZB GLRX2 NFE2 NFE2L2 NRIP2 RPS15A SIRT6 SS18L1 UBQLN4
Entrez ID		4778	2001
HPRD ID		09030	05525
Ensembl ID		ENSG00000123405	ENSG00000135374
Uniprot IDs		A8K3E0 Q16621	A0A087X1W9 A8K443 Q9UKW6
PDB IDs		1LVX 2KZ5	1WWX
Enriched GO Terms of Interacting Partners?
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