ELF5 and SIRT6

Number of citations of the paper that reports this interaction (PubMedID 16189514)
1103

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		ELF5	SIRT6
Description		E74 like ETS transcription factor 5	sirtuin 6
Image
GO Annotations	Cellular Component	Chromatin Nucleus	Nucleus Nucleoplasm Nucleolus Cytoplasm Chromosome, Subtelomeric Region
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Binding Sequence-specific Double-stranded DNA Binding	Transcription Corepressor Activity NAD+ ADP-ribosyltransferase Activity NAD(P)+-protein-arginine ADP-ribosyltransferase Activity Histone Deacetylase Activity Protein Binding Zinc Ion Binding NAD-dependent Histone Deacetylase Activity Deacetylase Activity NAD-dependent Protein Deacetylase Activity NAD-dependent Histone Deacetylase Activity (H3-K9 Specific) NAD+ Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Cell Differentiation	Negative Regulation Of Transcription By RNA Polymerase II Post-embryonic Cardiac Muscle Cell Growth Involved In Heart Morphogenesis Protein ADP-ribosylation Protein Deacetylation Regulation Of Double-strand Break Repair Via Homologous Recombination Response To Nutrient Levels Positive Regulation Of Telomere Maintenance Histone H3-K9 Modification Histone H3 Deacetylation Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of Transcription Factor Catabolic Process Positive Regulation Of Chondrocyte Proliferation Positive Regulation Of Blood Vessel Branching Positive Regulation Of Vascular Endothelial Cell Proliferation Histone H3-K9 Deacetylation
Pathways			Pre-NOTCH Transcription and Translation Processing of DNA double-strand break ends
Drugs
Diseases
GWAS		β2-Glycoprotein I (β2-GPI) plasma levels ( 23279374) Blood protein levels ( 28240269) Metabolite levels ( 23823483)
Interacting Genes		10 interacting genes: ACTR2 FRZB GLRX2 NFE2 NFE2L2 NRIP2 RPS15A SIRT6 SS18L1 UBQLN4	18 interacting genes: AKT1 CCNDBP1 CDKN1B CHD3 DDB2 ELF5 FAF1 HUS1 MUTYH RAD1 SKP2 STUB1 TDG TSPYL2 UBE2D1 UBE3A USP10 VIM
Entrez ID		2001	51548
HPRD ID		05525	12093
Ensembl ID		ENSG00000135374	ENSG00000077463
Uniprot IDs		A0A087X1W9 A8K443 Q9UKW6	B4DDV3 M0QXA0 M0R1N9 Q8N6T7
PDB IDs		1WWX	3K35 3PKI 3PKJ 3ZG6 5MF6 5MFP 5MFZ 5MGN 5X16 5Y2F 6HOY 6QCD 6QCE 6QCH 6QCJ 6XUY 6XV1 6XV6 6XVG 6ZU4 7CL0 7CL1
Enriched GO Terms of Interacting Partners?
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