NEK1 and FEZ2

Number of citations of the paper that reports this interaction (PubMedID 14690447)
34

Data Source:
HPRD (two hybrid, in vitro)

		NEK1	FEZ2
Description		NIMA related kinase 1	fasciculation and elongation protein zeta 2
Image			No pdb structure
GO Annotations	Cellular Component	Pericentriolar Material Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Centriolar Satellite	Cytoplasm Axon
	Molecular Function	Protein Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Metal Ion Binding 14-3-3 Protein Binding Protein Serine Kinase Activity	Protein Binding
	Biological Process	Protein Phosphorylation Cell Cycle Peptidyl-tyrosine Phosphorylation DNA Damage Response, Detection Of DNA Damage Cell Division Cilium Assembly	Signal Transduction Nervous System Development Axon Guidance Negative Regulation Of Autophagosome Assembly
Pathways
Drugs		Fostamatinib
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Daytime nap ( 33568662) Night sleep phenotypes ( 27126917) Schizophrenia ( 28991256 25056061 29483656) Supramarginal gyrus volume ( 31530798)	Apolipoprotein A1 levels ( 32203549) Haemorrhoidal disease ( 33888516) Hip circumference adjusted for BMI ( 34021172) Intraocular pressure ( 29617998) Metabolite levels ( 23823483) Offspring birth weight ( 31043758) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		27 interacting genes: ANXA10 ATRX CFAP410 CLCN3 CSN2 CTNNAL1 EXOSC4 FEZ1 FEZ2 GTF2H4 H2BC21 HAND2 HIP1R KIF3A LRRK1 LRRK2 MFHAS1 MRE11 PPP2R5A PTPRD RTN4R SIRPA TAF9 TP53BP1 TSC2 YWHAH ZNF350	18 interacting genes: BRD1 CLASP2 DRAP1 FEZ1 KPNA2 NEK1 PDCD7 PRKCZ RAB3GAP1 RAI14 SAP30L SCOC SMC3 TBC1D25 TEDC2 TLK2 WWC1 ZNF251
Entrez ID		4750	9637
HPRD ID		06847	09213
Ensembl ID		ENSG00000137601	ENSG00000171055
Uniprot IDs		Q5JXL9 Q96PY6	Q9UHY8
PDB IDs		4APC 4B9D
Enriched GO Terms of Interacting Partners?
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