NEK1 and CLCN3

		NEK1	CLCN3
Description		NIMA related kinase 1	chloride voltage-gated channel 3
Image			No pdb structure
GO Annotations	Cellular Component	Pericentriolar Material Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Centriolar Satellite	Golgi Membrane Lysosomal Membrane Early Endosome Late Endosome Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Synaptic Vesicle External Side Of Plasma Membrane Cell Surface Endosome Membrane Vesicle Membrane Membrane Integral Component Of Membrane Secretory Granule Cytoplasmic Vesicle Early Endosome Membrane Late Endosome Membrane Ruffle Membrane Specific Granule Intracellular Membrane-bounded Organelle Axon Terminus Phagocytic Vesicle Recycling Endosome Glutamatergic Synapse
	Molecular Function	Protein Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Metal Ion Binding 14-3-3 Protein Binding Protein Serine Kinase Activity	Voltage-gated Chloride Channel Activity Chloride Channel Activity Protein Binding ATP Binding Antiporter Activity Solute:proton Antiporter Activity PDZ Domain Binding Volume-sensitive Chloride Channel Activity
	Biological Process	Protein Phosphorylation Cell Cycle Peptidyl-tyrosine Phosphorylation DNA Damage Response, Detection Of DNA Damage Cell Division Cilium Assembly	Regulation Of PH Phagocytosis, Engulfment Adult Locomotory Behavior Synaptic Transmission, Glutamatergic Photoreceptor Cell Maintenance Negative Regulation Of Cell Volume Endosomal Lumen Acidification Synaptic Transmission, GABAergic Synaptic Vesicle Lumen Acidification Chloride Transmembrane Transport Positive Regulation Of Reactive Oxygen Species Biosynthetic Process
Pathways			Stimuli-sensing channels
Drugs		Fostamatinib
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Daytime nap ( 33568662) Night sleep phenotypes ( 27126917) Schizophrenia ( 28991256 25056061 29483656) Supramarginal gyrus volume ( 31530798)	Autism spectrum disorder or schizophrenia ( 28540026) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Schizophrenia ( 28991256 25056061 29483656 30285260)
Interacting Genes		27 interacting genes: ANXA10 ATRX CFAP410 CLCN3 CSN2 CTNNAL1 EXOSC4 FEZ1 FEZ2 GTF2H4 H2BC21 HAND2 HIP1R KIF3A LRRK1 LRRK2 MFHAS1 MRE11 PPP2R5A PTPRD RTN4R SIRPA TAF9 TP53BP1 TSC2 YWHAH ZNF350	17 interacting genes: ANXA10 CFTR DECR1 DNAJC5 ETFDH FZD3 GOPC GPRC5C GRIA2 HPF1 HSPB1 MED23 NEK1 PDGFB PDZK1 SLC9A3R1 VPS18
Entrez ID		4750	1182
HPRD ID		06847	02785
Ensembl ID		ENSG00000137601	ENSG00000109572
Uniprot IDs		Q5JXL9 Q96PY6	B3KXK0 P51790
PDB IDs		4APC 4B9D
Enriched GO Terms of Interacting Partners?
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