MYCN and YBX1

Number of citations of the paper that reports this interaction (PubMedID 17967896)
69

Data Source:
BioGRID (affinity chromatography technology, unspecified method)

		MYCN	YBX1
Description		MYCN proto-oncogene, bHLH transcription factor	Y-box binding protein 1
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Nucleolus	Extracellular Region Nucleus Nucleoplasm U12-type Spliceosomal Complex Cytoplasm Cytosol Cytoplasmic Stress Granule Nuclear Membrane Intracellular Membrane-bounded Organelle Extracellular Exosome CRD-mediated MRNA Stability Complex Histone Pre-mRNA 3'end Processing Complex Messenger Ribonucleoprotein Complex Ribonucleoprotein Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Kinase Binding Protein Dimerization Activity Sequence-specific Double-stranded DNA Binding	Nucleic Acid Binding DNA Binding Chromatin Binding Double-stranded DNA Binding Single-stranded DNA Binding RNA Binding MRNA Binding Protein Binding MiRNA Binding GTPase Binding C5-methylcytidine-containing RNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Cartilage Condensation Positive Regulation Of Mesenchymal Cell Proliferation Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Cell Death Lung Development Embryonic Digit Morphogenesis Regulation Of Inner Ear Auditory Receptor Cell Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Embryonic Skeletal System Morphogenesis Negative Regulation Of Astrocyte Differentiation Branching Morphogenesis Of An Epithelial Tube Positive Regulation Of Production Of MiRNAs Involved In Gene Silencing By MiRNA Negative Regulation Of Reactive Oxygen Species Metabolic Process	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Regulation Of Transcription, DNA-templated MRNA Processing RNA Splicing Epidermis Development Regulation Of Gene Expression Negative Regulation Of Translation Positive Regulation Of Transcription By RNA Polymerase II MRNA Stabilization Embryonic Morphogenesis RNA Transport TRNA Transport Negative Regulation Of Striated Muscle Cell Differentiation Positive Regulation Of Cell Division CRD-mediated MRNA Stabilization Cellular Response To Interleukin-7 Protein Localization To Cytoplasmic Stress Granule MiRNA Transport Negative Regulation Of Cellular Senescence
Pathways		Signaling by ALK	mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway Noncanonical activation of NOTCH3
Drugs
Diseases
GWAS		Asthma or chronic obstructive pulmonary disease ( 24993907) Basal cell carcinoma ( 25855136) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Height ( 31562340) Lymphocyte counts ( 32888494) Metabolite levels ( 23823483) Nonsyndromic cleft lip ( 31609978) Nonsyndromic cleft palate ( 31609978) Pulmonary function (smoking interaction) ( 23284291) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Wilms tumor ( 22544364)
Interacting Genes		20 interacting genes: CSNK2A1 CSNK2A2 DOT1L EZH2 FBXW7 GRSF1 HUWE1 MAX MXD1 NEDD4 NMI NONO RUNX3 SIRT1 SP1 TRIM32 YAF2 YBX1 YEATS4 ZBTB17	122 interacting genes: ACTA2 AKT1 ANKRD2 APBB1 C1QBP CALM1 CASP8 CSNK2A1 CTCF DANCR DUX4 FBXO33 FMR1 FUS GSK3B H1-2 HABP4 HLA-C HNRNPD HNRNPK IL7R IREB2 IRF1 JAM2 LCK LCP2 LSM3 MAPK1 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I MYC MYCN NFYB OGT PCBP2 PCNA PRPF40A PTPRF PURA RBBP6 RPS6KA1 RPS6KA3 SLC6A4 SMAD3 SMU1 SREK1 SRSF9 TFAP2A TP53 TRAF6 VEGFA VPS35
Entrez ID		4613	4904
HPRD ID		01278	01095
Ensembl ID		ENSG00000134323	ENSG00000065978
Uniprot IDs		A0A1W2PPD9 P04198 Q9H224	P67809
PDB IDs		5G1X	1H95 5YTS 5YTT 5YTV 5YTX 6A6L 6KTC 6KUG 6LMR 6LMS
Enriched GO Terms of Interacting Partners?
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