MYCN and DOT1L

Number of citations of the paper that reports this interaction (PubMedID 28209620)
27

Data Source:
BioGRID (affinity chromatography technology, pull down)

		MYCN	DOT1L
Description		MYCN proto-oncogene, bHLH transcription factor	DOT1 like histone lysine methyltransferase
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Nucleolus	Chromosome, Telomeric Region Nucleus Nucleoplasm Cytoplasm Protein-containing Complex Intracellular Membrane-bounded Organelle
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Kinase Binding Protein Dimerization Activity Sequence-specific Double-stranded DNA Binding	DNA Binding Protein Binding Histone-lysine N-methyltransferase Activity Histone Methyltransferase Activity (H3-K79 Specific) Histone Methyltransferase Activity
	Biological Process	Cartilage Condensation Positive Regulation Of Mesenchymal Cell Proliferation Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Cell Death Lung Development Embryonic Digit Morphogenesis Regulation Of Inner Ear Auditory Receptor Cell Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Embryonic Skeletal System Morphogenesis Negative Regulation Of Astrocyte Differentiation Branching Morphogenesis Of An Epithelial Tube Positive Regulation Of Production Of MiRNAs Involved In Gene Silencing By MiRNA Negative Regulation Of Reactive Oxygen Species Metabolic Process	DNA Damage Checkpoint Signaling DNA Repair Positive Regulation Of Cell Population Proliferation Gene Expression Telomere Organization Histone H3-K79 Methylation Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Receptor Signaling Pathway Via JAK-STAT Regulation Of Transcription Regulatory Region DNA Binding
Pathways		Signaling by ALK	PKMTs methylate histone lysines
Drugs
Diseases
GWAS		Asthma or chronic obstructive pulmonary disease ( 24993907) Basal cell carcinoma ( 25855136) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Height ( 31562340) Lymphocyte counts ( 32888494) Metabolite levels ( 23823483) Nonsyndromic cleft lip ( 31609978) Nonsyndromic cleft palate ( 31609978) Pulmonary function (smoking interaction) ( 23284291) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Wilms tumor ( 22544364)	Heel bone mineral density ( 30598549 28869591) Height ( 28552196 20881960 25282103 23563607 18391950) Hematocrit ( 29403010) Hemoglobin ( 29403010) Hemoglobin levels ( 32327693) Hip circumference adjusted for BMI ( 34021172 25673412) Hip minimal joint space width ( 27701424) Myocardial infarction ( 24916648) Osteoarthritis ( 22566624) Platelet count ( 32888494) Plateletcrit ( 32888494) Pulse pressure ( 26390057 27841878 29403010 27618448 30487518 30578418) Red blood cell count ( 29403010) Systemic lupus erythematosus ( 33493351) Systolic blood pressure ( 27618448 30487518) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) White blood cell count ( 32888494)
Interacting Genes		20 interacting genes: CSNK2A1 CSNK2A2 DOT1L EZH2 FBXW7 GRSF1 HUWE1 MAX MXD1 NEDD4 NMI NONO RUNX3 SIRT1 SP1 TRIM32 YAF2 YBX1 YEATS4 ZBTB17	4 interacting genes: H3-4 MLLT10 MYCN STAT1
Entrez ID		4613	84444
HPRD ID		01278	10455
Ensembl ID		ENSG00000134323	ENSG00000104885
Uniprot IDs		A0A1W2PPD9 P04198 Q9H224	Q8TEK3
PDB IDs		5G1X	1NW3 2MV7 3QOW 3QOX 3SR4 3SX0 3UWP 4EK9 4EKG 4EKI 4EQZ 4ER0 4ER3 4ER5 4ER6 4ER7 4HRA 4WVL 5DRT 5DRY 5DSX 5DT2 5DTM 5DTQ 5DTR 5JUW 5MVS 5MW3 5MW4 6IN3 6J99 6JM9 6JMA 6JN2 6NJ9 6NN6 6NOG 6NQA 6O96 6TE6 6TEL 6TEN
Enriched GO Terms of Interacting Partners?
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