MPP1 and DERL2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		MPP1	DERL2
Description		MAGUK p55 scaffold protein 1	derlin 2
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Cortical Cytoskeleton Stereocilium Centriolar Satellite	Hrd1p Ubiquitin Ligase ERAD-L Complex Early Endosome Late Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Endoplasmic Reticulum Membrane
	Molecular Function	Guanylate Kinase Activity Protein Binding	Signal Recognition Particle Binding Protein Binding Protein-containing Complex Binding Misfolded Protein Binding Ubiquitin-specific Protease Binding
	Biological Process	Signal Transduction GMP Metabolic Process GDP Metabolic Process Regulation Of Neutrophil Chemotaxis	Suckling Behavior Positive Regulation Of Cell Population Proliferation Positive Regulation Of Cell Growth Ubiquitin-dependent ERAD Pathway Endoplasmic Reticulum Unfolded Protein Response Retrograde Protein Transport, ER To Cytosol Negative Regulation Of Retrograde Protein Transport, ER To Cytosol
Pathways		Sensory processing of sound by outer hair cells of the cochlea	ABC-family proteins mediated transport Hedgehog ligand biogenesis Hh mutants are degraded by ERAD Defective CFTR causes cystic fibrosis ER Quality Control Compartment (ERQC)
Drugs
Diseases
GWAS		Hematology traits ( 23263863) Mean corpuscular volume ( 23263863) Red blood cell traits ( 23446634)	Asparaginase hypersensitivity in acute lymphoblastic leukemia ( 25987655)
Interacting Genes		46 interacting genes: ABCC4 ACER1 ACER2 AGPAT3 AMOTL2 AP2M1 APH1A ATP5F1C ATRAID BHLHB9 DERL2 DGAT2L6 DLG4 DNPEP ERBIN FXR2 GADD45A GSK3B GYPC HNRNPD INCA1 KLHL12 MAP3K20 MEOX2 NR1H2 OGT OPTN PAQR8 PRIMPOL RPRM RPS6KA1 RPS6KA6 SGSM2 SLC35E1 SMN1 SRSF10 STK3 STUB1 SYNGR3 TK1 TMEM239 TRIM55 TRIM63 USP21 UXT ZNF639	13 interacting genes: DIABLO FXYD6 KRTAP10-3 KRTAP10-7 KRTAP10-8 LMNA MELTF MMS22L MPP1 PTPN9 RBFA SERPINA1 SFT2D1
Entrez ID		4354	51009
HPRD ID		02370	16796
Ensembl ID		ENSG00000130830	ENSG00000072849
Uniprot IDs		B4E325 Q00013	I3L3R8 Q9GZP9
PDB IDs		2EJY 2EV8 3NEY
Enriched GO Terms of Interacting Partners?
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