MPG and HSD17B14

Number of citations of the paper that reports this interaction (PubMedID 25416956)
484

Data Source:
BioGRID (two hybrid, two hybrid)

		MPG	HSD17B14
Description		N-methylpurine DNA glycosylase	hydroxysteroid 17-beta dehydrogenase 14
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GO Annotations	Cellular Component	Nucleoplasm Cytosol Mitochondrial Nucleoid	Cytosol
	Molecular Function	Damaged DNA Binding Alkylbase DNA N-glycosylase Activity Protein Binding DNA-3-methyladenine Glycosylase Activity DNA N-glycosylase Activity DNA-7-methylguanine Glycosylase Activity DNA-7-methyladenine Glycosylase Activity DNA-3-methylguanine Glycosylase Activity	Estradiol 17-beta-dehydrogenase Activity Protein Binding Identical Protein Binding 17-beta-hydroxysteroid Dehydrogenase (NAD+) Activity Testosterone 17-beta-dehydrogenase (NADP+) Activity
	Biological Process	Base-excision Repair DNA Dealkylation Involved In DNA Repair Depurination	Steroid Catabolic Process
Pathways		Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Displacement of DNA glycosylase by APEX1	Estrogen biosynthesis
Drugs		Cisplatin Zinc Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Blood protein levels ( 30072576) Glioblastoma ( 28346443) Hemoglobin levels ( 26366553) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 32888494) Red blood cell traits ( 23446634)	Blood protein levels ( 30072576) Resting metabolic rate ( 28476931)
Interacting Genes		14 interacting genes: APP CRK EP300 ESR1 FBXO7 GPR182 HSD17B14 MLH1 RAD23A RAD23B RBFOX1 RXRA TERF2IP THRB	24 interacting genes: AKIRIN2 BRIP1 CA8 CDKN2D CYTOR DDIT3 INCA1 MIA3 MIR4435-2HG MPG NEK6 NTAQ1 NUDT18 OTUD3 PGLYRP3 PHF1 PICK1 PIDD1 PSMA1 REL SNAPC3 SNRPC SREK1IP1 TBC1D22B
Entrez ID		4350	51171
HPRD ID		06766	16801
Ensembl ID		ENSG00000103152	ENSG00000087076
Uniprot IDs		P29372 Q1W6H1	A0A140VJH8 Q9BPX1
PDB IDs		1BNK 1EWN 1F4R 1F6O 3QI5 3UBY	1YDE 5EN4 5HS6 5ICM 5ICS 5JS6 5JSF 5L7T 5L7W 5L7Y 5O42 5O43 5O6O 5O6X 5O6Z 5O72 5O7C 6EMM 6FFB 6G4L 6GBT 6GTB 6GTU 6H0M 6HNO 6QCK 6ZDE 6ZDI
Enriched GO Terms of Interacting Partners?
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