MCM6 and ORC1

Number of citations of the paper that reports this interaction (PubMedID 12614612)
25

Data Source:
BioGRID (two hybrid)

		MCM6	ORC1
Description		minichromosome maintenance complex component 6	origin recognition complex subunit 1
Image
GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm MCM Complex CMG Complex	Chromosome, Telomeric Region Origin Recognition Complex Nucleus Nucleoplasm Nuclear Origin Of Replication Recognition Complex Cytosol
	Molecular Function	DNA Helicase Activity Single-stranded DNA Binding Protein Binding ATP Binding ATP Hydrolysis Activity Single-stranded DNA Helicase Activity Identical Protein Binding Single-stranded 3'-5' DNA Helicase Activity	DNA Binding Chromatin Binding DNA Replication Origin Binding Protein Binding ATP Binding Metal Ion Binding
	Biological Process	Double-strand Break Repair Via Break-induced Replication DNA Replication DNA Unwinding Involved In DNA Replication DNA Replication Initiation Mitotic DNA Replication	DNA Replication Initiation Mitotic DNA Replication Checkpoint Signaling
Pathways		Activation of ATR in response to replication stress Unwinding of DNA Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex Switching of origins to a post-replicative state	E2F-enabled inhibition of pre-replication complex formation Activation of ATR in response to replication stress Assembly of the ORC complex at the origin of replication CDC6 association with the ORC:origin complex CDT1 association with the CDC6:ORC:origin complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex G1/S-Specific Transcription
Drugs
Diseases
GWAS		Aspartate aminotransferase levels ( 33547301) Body fat percentage and LDL-C (pairwise) ( 33619380) Body mass index ( 25673413) Body mass index and LDL-C (pairwise) ( 33619380) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Hip circumference ( 25673412) Total cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931)
Interacting Genes		37 interacting genes: C2CD6 CCNA1 CDC42 CDC45 CDC7 CDKN2A CDT1 CHEK1 CRLS1 DBF4 ESCO2 FAM161A GMNN HSPB1 IL36RN ING5 MCM10 MCM2 MCM3 MCM4 MCM7 MCM8 MCMBP MLLT3 MTDH NUDT2 ORC1 ORC2 ORC4 ORC6 PSMA1 RPA1 SCNM1 SMC1A SNRPB2 TRIM28 ZBTB9	25 interacting genes: CDC45 CDC5L CDC6 CDC7 CDK2 CDT1 DBF4 GOLGA2 GOLGA6L9 KAT7 MCM2 MCM4 MCM5 MCM6 MCM7 ORC2 ORC3 ORC4 ORC5 RB1 RFWD3 RPA2 SKP2 TMEM97 XPO1
Entrez ID		4175	4998
HPRD ID		03485	03544
Ensembl ID		ENSG00000076003	ENSG00000085840
Uniprot IDs		Q14566	B7Z8H0 Q13415 Q96F82
PDB IDs		2KLQ 2LE8 6XTX 6XTY	5UJ7 5UJM 6P3W 7CTF 7CTG 7JPO 7JPP 7JPR 7JPS
Enriched GO Terms of Interacting Partners?
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