MCM6 and CDC45

Number of citations of the paper that reports this interaction (PubMedID 12614612)
25

Data Source:
BioGRID (two hybrid, two hybrid)

		MCM6	CDC45
Description		minichromosome maintenance complex component 6	cell division cycle 45
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm MCM Complex CMG Complex	Nucleus Nucleoplasm Cytoplasm Centrosome DNA Replication Preinitiation Complex Ciliary Basal Body
	Molecular Function	DNA Helicase Activity Single-stranded DNA Binding Protein Binding ATP Binding ATP Hydrolysis Activity Single-stranded DNA Helicase Activity Identical Protein Binding Single-stranded 3'-5' DNA Helicase Activity	Chromatin Binding DNA Replication Origin Binding Single-stranded DNA Binding Protein Binding
	Biological Process	Double-strand Break Repair Via Break-induced Replication DNA Replication DNA Unwinding Involved In DNA Replication DNA Replication Initiation Mitotic DNA Replication	DNA Replication Checkpoint Signaling Double-strand Break Repair Via Break-induced Replication DNA Replication Initiation Mitotic DNA Replication Preinitiation Complex Assembly
Pathways		Activation of ATR in response to replication stress Unwinding of DNA Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex Switching of origins to a post-replicative state	Activation of ATR in response to replication stress Unwinding of DNA Activation of the pre-replicative complex G1/S-Specific Transcription
Drugs
Diseases
GWAS		Aspartate aminotransferase levels ( 33547301) Body fat percentage and LDL-C (pairwise) ( 33619380) Body mass index ( 25673413) Body mass index and LDL-C (pairwise) ( 33619380) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Hip circumference ( 25673412) Total cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931)	Cognitive decline rate in late mild cognitive impairment ( 26252872)
Interacting Genes		37 interacting genes: C2CD6 CCNA1 CDC42 CDC45 CDC7 CDKN2A CDT1 CHEK1 CRLS1 DBF4 ESCO2 FAM161A GMNN HSPB1 IL36RN ING5 MCM10 MCM2 MCM3 MCM4 MCM7 MCM8 MCMBP MLLT3 MTDH NUDT2 ORC1 ORC2 ORC4 ORC6 PSMA1 RPA1 SCNM1 SMC1A SNRPB2 TRIM28 ZBTB9	25 interacting genes: CAMK1G CDK4 CDKN1A CDKN2A CEP55 CSK GINS4 LCK MAPK3 MCM10 MCM2 MCM3 MCM6 MCM7 ORC1 ORC2 ORC3 ORC5 ORC6 POLA1 RAB4B TOPBP1 TRAPPC3 UBC ZRANB1
Entrez ID		4175	8318
HPRD ID		03485	09145
Ensembl ID		ENSG00000076003	ENSG00000093009
Uniprot IDs		Q14566	O75419
PDB IDs		2KLQ 2LE8 6XTX 6XTY	5DGO 6XTX 6XTY
Enriched GO Terms of Interacting Partners?
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