ORC1 and RFWD3

Number of citations of the paper that reports this interaction (PubMedID 33044890)
1

Data Source:
BioGRID (affinity chromatography technology, pull down)

		ORC1	RFWD3
Description		origin recognition complex subunit 1	ring finger and WD repeat domain 3
Image
GO Annotations	Cellular Component	Chromosome, Telomeric Region Origin Recognition Complex Nucleus Nucleoplasm Nuclear Origin Of Replication Recognition Complex Cytosol	Nucleus Nucleoplasm Cytoplasm PML Body Site Of Double-strand Break Site Of DNA Damage
	Molecular Function	DNA Binding Chromatin Binding DNA Replication Origin Binding Protein Binding ATP Binding Metal Ion Binding	P53 Binding Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity MDM2/MDM4 Family Protein Binding
	Biological Process	DNA Replication Initiation Mitotic DNA Replication Checkpoint Signaling	Double-strand Break Repair Via Homologous Recombination Cellular Response To DNA Damage Stimulus Response To Ionizing Radiation Protein Ubiquitination Chromosome Breakage Replication Fork Processing Mitotic G1 DNA Damage Checkpoint Signaling Interstrand Cross-link Repair Regulation Of DNA Damage Checkpoint
Pathways		E2F-enabled inhibition of pre-replication complex formation Activation of ATR in response to replication stress Assembly of the ORC complex at the origin of replication CDC6 association with the ORC:origin complex CDT1 association with the CDC6:ORC:origin complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex G1/S-Specific Transcription
Drugs
Diseases
GWAS			Adult body size ( 32376654) Experiencing mood swings ( 29500382) Leukocyte telomere length ( 32109421) Multiple myeloma ( 27363682) Testicular germ cell tumor ( 28604728 28604732 23666239)
Interacting Genes		25 interacting genes: CDC45 CDC5L CDC6 CDC7 CDK2 CDT1 DBF4 GOLGA2 GOLGA6L9 KAT7 MCM2 MCM4 MCM5 MCM6 MCM7 ORC2 ORC3 ORC4 ORC5 RB1 RFWD3 RPA2 SKP2 TMEM97 XPO1	15 interacting genes: APP ORC1 ORC2 PCNA RAD51 RPA1 RPA3 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E3 UBE2N UBE2W
Entrez ID		4998	55159
HPRD ID		03544	07678
Ensembl ID		ENSG00000085840	ENSG00000168411
Uniprot IDs		B7Z8H0 Q13415 Q96F82	Q6PCD5
PDB IDs		5UJ7 5UJM 6P3W 7CTF 7CTG 7JPO 7JPP 7JPR 7JPS	6CVZ
Enriched GO Terms of Interacting Partners?
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