MXD1 and SMC3

Number of citations of the paper that reports this interaction (PubMedID 9528857)
6

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		MXD1	SMC3
Description		MAX dimerization protein 1	structural maintenance of chromosomes 3
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GO Annotations	Cellular Component	Chromatin Nucleoplasm Mitochondrion Cytosol	Chromosome, Centromeric Region Chromatin Lateral Element Nucleoplasm Chromosome Cytosol Cohesin Complex Nuclear Matrix Meiotic Cohesin Complex Nuclear Mitotic Cohesin Complex Nuclear Meiotic Cohesin Complex Mitotic Spindle Pole
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Protein Binding Protein Dimerization Activity	Chromatin Binding Double-stranded DNA Binding Microtubule Motor Activity Protein Binding ATP Binding Mediator Complex Binding Protein Heterodimerization Activity Beta-tubulin Binding Cohesin Loading Activity Dynein Complex Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II	Mitotic Cell Cycle Regulation Of DNA Replication DNA Repair Sister Chromatid Cohesion Mitotic Sister Chromatid Cohesion Stem Cell Population Maintenance Cell Division Meiotic Cell Cycle Mitotic Spindle Assembly
Pathways			Meiotic synapsis Separation of Sister Chromatids Establishment of Sister Chromatid Cohesion Cohesin Loading onto Chromatin Resolution of Sister Chromatid Cohesion SUMOylation of DNA damage response and repair proteins Estrogen-dependent gene expression
Drugs
Diseases
GWAS		Carotid plaque burden (smoking interaction) ( 24954085) High light scatter reticulocyte count ( 32888494 27863252) Mean platelet volume ( 32888494 27863252) Platelet count ( 32888494 27863252) Red cell distribution width ( 28957414) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)	Acute respiratory distress syndrome in sepsis ( 31982041) Lumbar spine bone mineral density (integral) ( 27476799) Metabolite levels ( 23823483)
Interacting Genes		20 interacting genes: AKT1 APP CD2 HDAC1 HDAC2 MAX MLX MOGS MYC MYCL MYCN PML PRAM1 REL RPS6KA1 RPS6KB1 SAP30 SIN3A SIN3B SMC3	19 interacting genes: APC CEP63 CYP27B1 DISC1 ESCO2 ESR1 FEZ1 FEZ2 KIFAP3 MTNR1B MXD1 MXD3 MXD4 MXI1 RPGR SMC1A SMC1B SUMO2 TRAF3IP1
Entrez ID		4084	9126
HPRD ID		02487	05829
Ensembl ID		ENSG00000059728	ENSG00000108055
Uniprot IDs		B7ZLI7 Q05195	Q9UQE7
PDB IDs		1E91 1G1E 1NLW 1PD7 1S5Q	6WG3 6WG4 6WG6 6WGE
Enriched GO Terms of Interacting Partners?
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