HSD17B11 and AGPAT3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		HSD17B11	AGPAT3
Description		hydroxysteroid 17-beta dehydrogenase 11	1-acylglycerol-3-phosphate O-acyltransferase 3
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Lipid Droplet Cytosol	Golgi Membrane Nuclear Envelope Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Endomembrane System Membrane Integral Component Of Membrane
	Molecular Function	Estradiol 17-beta-dehydrogenase Activity Protein Binding Steroid Dehydrogenase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor 17-beta-hydroxysteroid Dehydrogenase (NAD+) Activity 17-beta-hydroxysteroid Dehydrogenase (NADP+) Activity	1-acylglycerol-3-phosphate O-acyltransferase Activity Protein Binding Acyltransferase Activity
	Biological Process	Estrogen Biosynthetic Process Androgen Catabolic Process	Phosphatidic Acid Biosynthetic Process Phospholipid Biosynthetic Process CDP-diacylglycerol Biosynthetic Process
Pathways		Estrogen biosynthesis	Synthesis of PA COPI-independent Golgi-to-ER retrograde traffic
Drugs		Aetiocholanolone
Diseases
GWAS		Appendicular lean mass ( 28724990) Bulimia nervosa ( 23568457) Lean body mass ( 28724990)	Adverse response to drug ( 30420678) Estimated glomerular filtration rate in diabetes ( 31451708) Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid) ( 21829377)
Interacting Genes		54 interacting genes: ADIPOQ AGPAT3 AGPAT4 ANKRD46 BNIP1 CMTM3 CSGALNACT2 CYBC1 DGAT2L6 DHRSX EHHADH ERG28 FAM241B GIMAP1 GOLT1A HTATIP2 LRCH4 MS4A1 NEU1 ORMDL1 OTULINL PLP2 PRAF2 PTPN9 RASGRP3 RMDN2 RTP2 SEC22A SERPINE1 SFRP4 SFT2D2 SFXN3 SLC22A18 SLC25A46 SLC30A8 STRIT1 STX7 SYS1 TMEM120B TMEM128 TMEM14B TMEM167B TMEM203 TMEM242 TMEM42 TMEM65 TMX2 TPRG1 TTPA TVP23B UBC UNC50 VEZT YIPF6	19 interacting genes: ABHD16A APP AQP6 BNIP2 CREB3 CREB3L1 FAM133A GOLT1A HSD17B11 HSD17B13 MFSD14B MPP1 NKAPD1 SLC10A1 SLC35C2 SREK1IP1 TMEM14B TMEM167B TMX2
Entrez ID		51170	56894
HPRD ID		10881	10637
Ensembl ID		ENSG00000198189	ENSG00000160216
Uniprot IDs		Q8NBQ5	Q9NRZ7
PDB IDs		1YB1
Enriched GO Terms of Interacting Partners?
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