HSD17B11 and RASGRP3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		HSD17B11	RASGRP3
Description		hydroxysteroid 17-beta dehydrogenase 11	RAS guanyl releasing protein 3
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Lipid Droplet Cytosol	Plasma Membrane Integral Component Of Plasma Membrane Guanyl-nucleotide Exchange Factor Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Estradiol 17-beta-dehydrogenase Activity Protein Binding Steroid Dehydrogenase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor 17-beta-hydroxysteroid Dehydrogenase (NAD+) Activity 17-beta-hydroxysteroid Dehydrogenase (NADP+) Activity	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Calcium Ion Binding Protein Binding Kinase Binding Diacylglycerol Binding Small GTPase Binding
	Biological Process	Estrogen Biosynthetic Process Androgen Catabolic Process	MAPK Cascade Small GTPase Mediated Signal Transduction Ras Protein Signal Transduction Regulation Of GTPase Activity
Pathways		Estrogen biosynthesis	Activation of RAS in B cells Activation of RAS in B cells RAF/MAP kinase cascade
Drugs		Aetiocholanolone
Diseases
GWAS		Appendicular lean mass ( 28724990) Bulimia nervosa ( 23568457) Lean body mass ( 28724990)	Albumin-globulin ratio ( 29403010) Bronchopulmonary dysplasia in preterm infants ( 30113228) Hypertension (young onset) ( 19421330) IgG response to Plasmodium falciparum antigens (GLURP, MSP2 FC27, MSP2 3D7) ( 26741287) Metabolite levels ( 23823483) Multiple system atrophy (pathologically confirmed) ( 27629089) Non-albumin protein levels ( 29403010) Non-response to antidepressants and depression ( 27622933) SjÃ¶gren's syndrome ( 24097067) Systemic lupus erythematosus ( 27399966 23273568 33272962 26663301 28714469 19838193)
Interacting Genes		54 interacting genes: ADIPOQ AGPAT3 AGPAT4 ANKRD46 BNIP1 CMTM3 CSGALNACT2 CYBC1 DGAT2L6 DHRSX EHHADH ERG28 FAM241B GIMAP1 GOLT1A HTATIP2 LRCH4 MS4A1 NEU1 ORMDL1 OTULINL PLP2 PRAF2 PTPN9 RASGRP3 RMDN2 RTP2 SEC22A SERPINE1 SFRP4 SFT2D2 SFXN3 SLC22A18 SLC25A46 SLC30A8 STRIT1 STX7 SYS1 TMEM120B TMEM128 TMEM14B TMEM167B TMEM203 TMEM242 TMEM42 TMEM65 TMX2 TPRG1 TTPA TVP23B UBC UNC50 VEZT YIPF6	12 interacting genes: APP DYNC2LI1 DYNLL2 GET1 HSD17B11 PIK3CA PRKACA PRKCB PRKCD PRKCE PRKCQ SULT1C2
Entrez ID		51170	25780
HPRD ID		10881	15213
Ensembl ID		ENSG00000198189	ENSG00000152689
Uniprot IDs		Q8NBQ5	Q8IV61
PDB IDs		1YB1
Enriched GO Terms of Interacting Partners?
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