ARHGAP5 and PTPN18

Number of citations of the paper that reports this interaction (PubMedID 15588985)
74

Data Source:
HPRD (in vivo)

		ARHGAP5	PTPN18
Description		Rho GTPase activating protein 5	protein tyrosine phosphatase non-receptor type 18
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GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Cytosol Plasma Membrane	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	GTPase Activity GTPase Activator Activity Protein Binding GTP Binding SH2 Domain Binding	Protein Tyrosine Phosphatase Activity Non-membrane Spanning Protein Tyrosine Phosphatase Activity Protein Binding
	Biological Process	Cell Adhesion Rho Protein Signal Transduction Mammary Gland Development Regulation Of Catalytic Activity Regulation Of Small GTPase Mediated Signal Transduction	Blastocyst Formation Protein Dephosphorylation Peptidyl-tyrosine Dephosphorylation Negative Regulation Of ERBB Signaling Pathway
Pathways		RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RHOD GTPase cycle RHOQ GTPase cycle RHOG GTPase cycle RHOJ GTPase cycle RAC3 GTPase cycle RHOF GTPase cycle RND3 GTPase cycle RND2 GTPase cycle RND1 GTPase cycle	Downregulation of ERBB2 signaling Interleukin-37 signaling
Drugs
Diseases
GWAS		Asthma ( 29273806)
Interacting Genes		12 interacting genes: ADRB2 ITGA5 ITGB1 PTK2B PTPN18 RASA1 RHOA RND1 RND2 RND3 SMURF2 SUZ12	12 interacting genes: AATK ABL1 ARHGAP5 CDK2 CSK EGFR ERBB2 GAB1 PSTPIP1 PSTPIP2 SRC TEC
Entrez ID		394	26469
HPRD ID		04060	05961
Ensembl ID		ENSG00000100852	ENSG00000072135
Uniprot IDs		Q13017	Q99952
PDB IDs		2EE4 2EE5 5U4V	2OC3 4GFU 4GFV 4NND
Enriched GO Terms of Interacting Partners?
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