ARHGAP5 and RND3

Number of citations of the paper that reports this interaction (PubMedID 12842009)
86

Data Source:
BioGRID (two hybrid, affinity chromatography technology, pull down)
HPRD (in vitro, two hybrid, in vivo)

		ARHGAP5	RND3
Description		Rho GTPase activating protein 5	Rho family GTPase 3
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GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Cytosol Plasma Membrane	Golgi Membrane Cytoskeleton Plasma Membrane Focal Adhesion Cell Cortex Cytoplasmic Vesicle Cell Projection
	Molecular Function	GTPase Activity GTPase Activator Activity Protein Binding GTP Binding SH2 Domain Binding	GTPase Activity Protein Binding GTP Binding Protein Kinase Binding
	Biological Process	Cell Adhesion Rho Protein Signal Transduction Mammary Gland Development Regulation Of Catalytic Activity Regulation Of Small GTPase Mediated Signal Transduction	Actin Filament Organization Cell Adhesion Establishment Or Maintenance Of Cell Polarity Small GTPase Mediated Signal Transduction Regulation Of Cell Shape Cell Migration Actin Cytoskeleton Organization Cortical Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization
Pathways		RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RHOD GTPase cycle RHOQ GTPase cycle RHOG GTPase cycle RHOJ GTPase cycle RAC3 GTPase cycle RHOF GTPase cycle RND3 GTPase cycle RND2 GTPase cycle RND1 GTPase cycle	RND3 GTPase cycle
Drugs			Guanosine-5'-Triphosphate
Diseases
GWAS		Asthma ( 29273806)	Arterial stiffness (brachial-ankle pulse wave velocity) ( 32790701) Daytime nap ( 33568662) Endometriosis ( 23472165) Esophageal adenocarcinoma x gastroesophageal reflux disease interaction ( 29551738) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Neonatal total 25-hydroxyvitamin D levels (fetal genetic effect) ( 32047095) Platelet count ( 31217584) Reticulocyte fraction of red cells ( 32888494) Type 2 diabetes ( 22238593) Urinary metabolite levels in chronic kidney disease ( 29545352)
Interacting Genes		12 interacting genes: ADRB2 ITGA5 ITGB1 PTK2B PTPN18 RASA1 RHOA RND1 RND2 RND3 SMURF2 SUZ12	10 interacting genes: ARHGAP5 C14orf119 CDH5 CIT CPLANE2 GCH1 PLXNB1 ROCK1 SKP2 UBXN11
Entrez ID		394	390
HPRD ID		04060	04233
Ensembl ID		ENSG00000100852	ENSG00000115963
Uniprot IDs		Q13017	B2R838 P61587
PDB IDs		2EE4 2EE5 5U4V	1M7B 2V55 4BG6
Enriched GO Terms of Interacting Partners?
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