LAMB1 and ACHE

Number of citations of the paper that reports this interaction (PubMedID 15474030)
7

Data Source:
HPRD (in vivo, in vitro, two hybrid)

		LAMB1	ACHE
Description		laminin subunit beta 1	acetylcholinesterase (Cartwright blood group)
Image
GO Annotations	Cellular Component	Extracellular Region Basement Membrane Laminin-1 Complex Laminin-2 Complex Extracellular Space Endoplasmic Reticulum Lumen Laminin Complex Laminin-8 Complex Laminin-10 Complex Perinuclear Region Of Cytoplasm Collagen-containing Extracellular Matrix Extracellular Exosome	Extracellular Region Basement Membrane Extracellular Space Nucleus Golgi Apparatus Plasma Membrane Cell Surface Membrane Anchored Component Of Membrane Neuromuscular Junction Synaptic Cleft Synapse Perinuclear Region Of Cytoplasm
	Molecular Function	Integrin Binding Structural Molecule Activity Extracellular Matrix Structural Constituent Protein Binding	Amyloid-beta Binding Acetylcholinesterase Activity Cholinesterase Activity Protein Binding Collagen Binding Hydrolase Activity Serine Hydrolase Activity Acetylcholine Binding Protein Homodimerization Activity Laminin Binding Protein Self-association
	Biological Process	Cell Adhesion Animal Organ Morphogenesis Tissue Development Cell Migration Neuronal-glial Interaction Involved In Cerebral Cortex Radial Glia Guided Migration Positive Regulation Of Cell Migration Neuron Projection Development Substrate Adhesion-dependent Cell Spreading Endodermal Cell Differentiation Odontogenesis Positive Regulation Of Epithelial Cell Proliferation Basement Membrane Assembly	Acetylcholine Catabolic Process In Synaptic Cleft Regulation Of Receptor Recycling Osteoblast Development Acetylcholine Catabolic Process Phosphatidylcholine Biosynthetic Process Cell Adhesion Nervous System Development Synapse Assembly Receptor Internalization Negative Regulation Of Synaptic Transmission, Cholinergic Neurotransmitter Biosynthetic Process Amyloid Precursor Protein Metabolic Process Positive Regulation Of Protein Secretion Retina Development In Camera-type Eye Acetylcholine Receptor Signaling Pathway Positive Regulation Of Cold-induced Thermogenesis
Pathways		Degradation of the extracellular matrix Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions ECM proteoglycans L1CAM interactions Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) MET activates PTK2 signaling Post-translational protein phosphorylation EGR2 and SOX10-mediated initiation of Schwann cell myelination	Neurotransmitter clearance Synthesis of PC Synthesis, secretion, and deacylation of Ghrelin
Drugs		Lanoteplase	Choline Tacrine Carbamoylcholine Dipivefrin Gallamine triethiodide Pyridostigmine Galantamine Isoflurophate Pralidoxime Minaprine Donepezil Ranitidine Demecarium Physostigmine Rivastigmine Edrophonium Ambenonium Tubocurarine Decamethonium Neostigmine Monoisopropylphosphorylserine Propidium 3,8-Diamino-6-Phenyl-5-[6-[1-[2-[(1,2,3,4-Tetrahydro-9-Acridinyl)Amino]Ethyl]-1h-1,2,3-Triazol-4-Yl]Hexyl]-Phenanthridinium 3,6,9,12,15-Pentaoxaheptadecane 1-Deoxy-1-Thio-Heptaethylene Glycol (4aS,6R,8aS)-11-[8-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)octyl]-6-hydroxy-3-methoxy-5,6,9,10-tetrahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-11-ium Methylphosphinate Methylphosphinic Acid 3,8-Diamino-6-Phenyl-5-[6-[1-[2-[(1,2,3,4-Tetrahydro-9-Acridinyl)Amino]Ethyl]-1h-1,2,3-Triazol-5-Yl]Hexyl]-Phenanthridinium Acetylcholine beta-L-fucose Huperzine B M-(N,N,N-Trimethylammonio)-2,2,2-Trifluoro-1,1-Dihydroxyethylbenzene N-acetyl-alpha-D-glucosamine 2-(N-morpholino)ethanesulfonic acid MF268 3-Chloro-9-Ethyl-6,7,8,9,10,11-Hexahydro-7,11-Methanocycloocta[B]Quinolin-12-Amine NAP-226-90 (R)-tacrine(10)-hupyridone (S)-tacrine(10)-hupyridone TACRINE(8)-4-AMINOQUINOLINE (9S)-9-[(8-AMMONIOOCTYL)AMINO]-1,2,3,4,9,10-HEXAHYDROACRIDINIUM Zanapezil Huperzine A Phenserine Itopride Ganstigmine Hydroxy(oxo)(2-{(1S)-2,2,2-trifluoro-1-[2-(trimethylarsonio)ethoxy]ethyl}phenyl)ammonium 1-BENZYL-4-[(5,6-DIMETHOXY-1-INDANON-2-YL)METHYL]PIPERIDINE 1-[3-({[(4-AMINO-5-FLUORO-2-METHYLQUINOLIN-3-YL)METHYL]THIO}METHYL)PHENYL]-2,2,2-TRIFLUOROETHANE-1,1-DIOL (3,4,8b-Trimethyl-3-oxido-2,3a-dihydro-1H-pyrrolo[2,3-b]indol-3-ium-7-yl) N-(2-ethylphenyl)carbamate Methylthioninium Diethylene glycol diethyl ether 2-[4-(DIMETHYLAMINO)PHENYL]-6-HYDROXY-3-METHYL-1,3-BENZOTHIAZOL-3-IUM Dimetacrine Tyrothricin Choline salicylate
Diseases
GWAS		Body shape index ( 34021172) IgG glycosylation ( 23382691) Inflammatory bowel disease ( 28067908) Latent naming speed ( 30995994) Pneumoconiosis in silica exposure ( 24986923) Rapid alternating stimulus test for letters/numbers ( 30995994) Rapid automised naming and rapid alternating stimulus test performance ( 30995994) Rapid automised naming of letters ( 30995994) Ulcerative colitis ( 19915572 28067908 20228799 19122664) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Bipolar disorder ( 31043756) Body mass index ( 29273807) Diastolic blood pressure ( 30578418) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Heart rate ( 23583979) Heart rate increase in response to exercise ( 29497042) Heart rate response to recovery post exercise ( 29769521) Heart rate response to recovery post exercise (10 sec) ( 29497042) Heart rate response to recovery post exercise (20 sec) ( 29497042) Heart rate response to recovery post exercise (30 sec) ( 29497042) Heart rate response to recovery post exercise (40 sec) ( 29497042) Heart rate response to recovery post exercise (50 sec) ( 29497042) Heel bone mineral density ( 30598549) Hemoglobin levels ( 32327693) Nonunion in individuals with fractures ( 30680360) Plasminogen activator inhibitor type 1 levels (PAI-1) ( 22990020) Pulse pressure ( 27841878) Resting heart rate ( 27798624) Type 2 diabetes ( 21490949)
Interacting Genes		15 interacting genes: ACHE ANTXR2 ATXN7 ATXN7L2 CACNA1A CD79A COL6A1 ERBIN GFI1B GPR152 LMNA PRKAR2B PSMC5 UBC UBQLN1	9 interacting genes: APP CDK6 COL4A1 COLQ EIF2D HAND1 LAMA1 LAMB1 PRIMA1
Entrez ID		3912	43
HPRD ID		01029	00010
Ensembl ID		ENSG00000091136	ENSG00000087085
Uniprot IDs		G3XAI2 P07942 Q8TAS6	P22303
PDB IDs		5XAU	1B41 1F8U 1PUV 1PUW 1VZJ 2CLJ 2X8B 3LII 4BDT 4EY4 4EY5 4EY6 4EY7 4EY8 4M0E 4M0F 4PQE 5FOQ 5FPQ 5HF5 5HF6 5HF8 5HF9 5HFA 6CQT 6CQU 6CQV 6CQW 6CQX 6CQY 6CQZ 6F25 6NEA 6NTG 6NTH 6NTK 6NTL 6NTM 6NTN 6NTO 6O4W 6O4X 6O50 6O52 6O5R 6O5S 6O5V 6O66 6O69 6U34 6U37 6U3P 6WUV 6WUY 6WUZ 6WV1 6WVC 6WVP 6WVQ
Enriched GO Terms of Interacting Partners?
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