ACHE and EIF2D

Number of citations of the paper that reports this interaction (PubMedID 7085778)
3

Data Source:
HPRD (in vivo)

		ACHE	EIF2D
Description		acetylcholinesterase (Cartwright blood group)	eukaryotic translation initiation factor 2D
Image
GO Annotations	Cellular Component	Extracellular Region Basement Membrane Extracellular Space Nucleus Golgi Apparatus Plasma Membrane Cell Surface Membrane Anchored Component Of Membrane Neuromuscular Junction Synaptic Cleft Synapse Perinuclear Region Of Cytoplasm	Cytoplasm Cytosol Nuclear Body
	Molecular Function	Amyloid-beta Binding Acetylcholinesterase Activity Cholinesterase Activity Protein Binding Collagen Binding Hydrolase Activity Serine Hydrolase Activity Acetylcholine Binding Protein Homodimerization Activity Laminin Binding Protein Self-association	Translation Initiation Factor Activity Signaling Receptor Activity
	Biological Process	Acetylcholine Catabolic Process In Synaptic Cleft Regulation Of Receptor Recycling Osteoblast Development Acetylcholine Catabolic Process Phosphatidylcholine Biosynthetic Process Cell Adhesion Nervous System Development Synapse Assembly Receptor Internalization Negative Regulation Of Synaptic Transmission, Cholinergic Neurotransmitter Biosynthetic Process Amyloid Precursor Protein Metabolic Process Positive Regulation Of Protein Secretion Retina Development In Camera-type Eye Acetylcholine Receptor Signaling Pathway Positive Regulation Of Cold-induced Thermogenesis	Formation Of Translation Preinitiation Complex Intracellular Protein Transport Ribosome Disassembly IRES-dependent Viral Translational Initiation
Pathways		Neurotransmitter clearance Synthesis of PC Synthesis, secretion, and deacylation of Ghrelin
Drugs		Choline Tacrine Carbamoylcholine Dipivefrin Gallamine triethiodide Pyridostigmine Galantamine Isoflurophate Pralidoxime Minaprine Donepezil Ranitidine Demecarium Physostigmine Rivastigmine Edrophonium Ambenonium Tubocurarine Decamethonium Neostigmine Monoisopropylphosphorylserine Propidium 3,8-Diamino-6-Phenyl-5-[6-[1-[2-[(1,2,3,4-Tetrahydro-9-Acridinyl)Amino]Ethyl]-1h-1,2,3-Triazol-4-Yl]Hexyl]-Phenanthridinium 3,6,9,12,15-Pentaoxaheptadecane 1-Deoxy-1-Thio-Heptaethylene Glycol (4aS,6R,8aS)-11-[8-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)octyl]-6-hydroxy-3-methoxy-5,6,9,10-tetrahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-11-ium Methylphosphinate Methylphosphinic Acid 3,8-Diamino-6-Phenyl-5-[6-[1-[2-[(1,2,3,4-Tetrahydro-9-Acridinyl)Amino]Ethyl]-1h-1,2,3-Triazol-5-Yl]Hexyl]-Phenanthridinium Acetylcholine beta-L-fucose Huperzine B M-(N,N,N-Trimethylammonio)-2,2,2-Trifluoro-1,1-Dihydroxyethylbenzene N-acetyl-alpha-D-glucosamine 2-(N-morpholino)ethanesulfonic acid MF268 3-Chloro-9-Ethyl-6,7,8,9,10,11-Hexahydro-7,11-Methanocycloocta[B]Quinolin-12-Amine NAP-226-90 (R)-tacrine(10)-hupyridone (S)-tacrine(10)-hupyridone TACRINE(8)-4-AMINOQUINOLINE (9S)-9-[(8-AMMONIOOCTYL)AMINO]-1,2,3,4,9,10-HEXAHYDROACRIDINIUM Zanapezil Huperzine A Phenserine Itopride Ganstigmine Hydroxy(oxo)(2-{(1S)-2,2,2-trifluoro-1-[2-(trimethylarsonio)ethoxy]ethyl}phenyl)ammonium 1-BENZYL-4-[(5,6-DIMETHOXY-1-INDANON-2-YL)METHYL]PIPERIDINE 1-[3-({[(4-AMINO-5-FLUORO-2-METHYLQUINOLIN-3-YL)METHYL]THIO}METHYL)PHENYL]-2,2,2-TRIFLUOROETHANE-1,1-DIOL (3,4,8b-Trimethyl-3-oxido-2,3a-dihydro-1H-pyrrolo[2,3-b]indol-3-ium-7-yl) N-(2-ethylphenyl)carbamate Methylthioninium Diethylene glycol diethyl ether 2-[4-(DIMETHYLAMINO)PHENYL]-6-HYDROXY-3-METHYL-1,3-BENZOTHIAZOL-3-IUM Dimetacrine Tyrothricin Choline salicylate
Diseases
GWAS		Bipolar disorder ( 31043756) Body mass index ( 29273807) Diastolic blood pressure ( 30578418) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Heart rate ( 23583979) Heart rate increase in response to exercise ( 29497042) Heart rate response to recovery post exercise ( 29769521) Heart rate response to recovery post exercise (10 sec) ( 29497042) Heart rate response to recovery post exercise (20 sec) ( 29497042) Heart rate response to recovery post exercise (30 sec) ( 29497042) Heart rate response to recovery post exercise (40 sec) ( 29497042) Heart rate response to recovery post exercise (50 sec) ( 29497042) Heel bone mineral density ( 30598549) Hemoglobin levels ( 32327693) Nonunion in individuals with fractures ( 30680360) Plasminogen activator inhibitor type 1 levels (PAI-1) ( 22990020) Pulse pressure ( 27841878) Resting heart rate ( 27798624) Type 2 diabetes ( 21490949)	Ceramide levels (C24:0) ( 32489964)
Interacting Genes		9 interacting genes: APP CDK6 COL4A1 COLQ EIF2D HAND1 LAMA1 LAMB1 PRIMA1	3 interacting genes: ACHE HEXB PTPRC
Entrez ID		43	1939
HPRD ID		00010	01057
Ensembl ID		ENSG00000087085	ENSG00000143486
Uniprot IDs		P22303	P41214
PDB IDs		1B41 1F8U 1PUV 1PUW 1VZJ 2CLJ 2X8B 3LII 4BDT 4EY4 4EY5 4EY6 4EY7 4EY8 4M0E 4M0F 4PQE 5FOQ 5FPQ 5HF5 5HF6 5HF8 5HF9 5HFA 6CQT 6CQU 6CQV 6CQW 6CQX 6CQY 6CQZ 6F25 6NEA 6NTG 6NTH 6NTK 6NTL 6NTM 6NTN 6NTO 6O4W 6O4X 6O50 6O52 6O5R 6O5S 6O5V 6O66 6O69 6U34 6U37 6U3P 6WUV 6WUY 6WUZ 6WV1 6WVC 6WVP 6WVQ	5OA3 5OA9 5W2F
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?