LAMB1 and COL6A1

Number of citations of the paper that reports this interaction (PubMedID 10407855)
7

Data Source:
HPRD (in vivo)

		LAMB1	COL6A1
Description		laminin subunit beta 1	collagen type VI alpha 1 chain
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Basement Membrane Laminin-1 Complex Laminin-2 Complex Extracellular Space Endoplasmic Reticulum Lumen Laminin Complex Laminin-8 Complex Laminin-10 Complex Perinuclear Region Of Cytoplasm Collagen-containing Extracellular Matrix Extracellular Exosome	Extracellular Region Collagen Type VI Trimer Extracellular Space Lysosomal Membrane Endoplasmic Reticulum Lumen Membrane Protein-containing Complex Sarcolemma Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	Integrin Binding Structural Molecule Activity Extracellular Matrix Structural Constituent Protein Binding	Collagen Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength Platelet-derived Growth Factor Binding
	Biological Process	Cell Adhesion Animal Organ Morphogenesis Tissue Development Cell Migration Neuronal-glial Interaction Involved In Cerebral Cortex Radial Glia Guided Migration Positive Regulation Of Cell Migration Neuron Projection Development Substrate Adhesion-dependent Cell Spreading Endodermal Cell Differentiation Odontogenesis Positive Regulation Of Epithelial Cell Proliferation Basement Membrane Assembly	Osteoblast Differentiation Cell Adhesion Endodermal Cell Differentiation Cellular Response To Amino Acid Stimulus
Pathways		Degradation of the extracellular matrix Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions ECM proteoglycans L1CAM interactions Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) MET activates PTK2 signaling Post-translational protein phosphorylation EGR2 and SOX10-mediated initiation of Schwann cell myelination	Collagen degradation Collagen biosynthesis and modifying enzymes Signaling by PDGF Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions ECM proteoglycans ECM proteoglycans NCAM1 interactions Collagen chain trimerization
Drugs		Lanoteplase
Diseases
GWAS		Body shape index ( 34021172) IgG glycosylation ( 23382691) Inflammatory bowel disease ( 28067908) Latent naming speed ( 30995994) Pneumoconiosis in silica exposure ( 24986923) Rapid alternating stimulus test for letters/numbers ( 30995994) Rapid automised naming and rapid alternating stimulus test performance ( 30995994) Rapid automised naming of letters ( 30995994) Ulcerative colitis ( 19915572 28067908 20228799 19122664) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Blood protein levels ( 30072576 29875488) Bone mineral density (lumbar spine) in inflammatory bowel disease ( 29603369) Corneal hysteresis ( 32716492 30894546) Corneal resistance factor ( 31246245 32716492 30894546) Daytime nap ( 33568662) Diverticular disease ( 30177863) Intraocular pressure ( 29617998 29235454) Keratoconus ( 33649486) Myopia ( 27182965) Pulse pressure ( 30224653 30578418) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Systolic blood pressure ( 28234671) Waist circumference adjusted for body mass index ( 34021172 25673412)
Interacting Genes		15 interacting genes: ACHE ANTXR2 ATXN7 ATXN7L2 CACNA1A CD79A COL6A1 ERBIN GFI1B GPR152 LMNA PRKAR2B PSMC5 UBC UBQLN1	24 interacting genes: ALDH3A2 CFAP410 COL2A1 COL6A2 CSTB DCN DNAJB11 FAM3B FGF7 HCFC2 LAMB1 LCMT2 LGALS3BP MAG MLLT3 MPRIP MTDH PCNT PDGFA PDGFB PDK1 PEX26 PIGS RUNX1
Entrez ID		3912	1291
HPRD ID		01029	00370
Ensembl ID		ENSG00000091136	ENSG00000142156
Uniprot IDs		G3XAI2 P07942 Q8TAS6	A0A384P5H7 P12109
PDB IDs		5XAU
Enriched GO Terms of Interacting Partners?
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