COL6A1 and ALDH3A2

		COL6A1	ALDH3A2
Description		collagen type VI alpha 1 chain	aldehyde dehydrogenase 3 family member A2
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Collagen Type VI Trimer Extracellular Space Lysosomal Membrane Endoplasmic Reticulum Lumen Membrane Protein-containing Complex Sarcolemma Collagen-containing Extracellular Matrix Extracellular Exosome	Cytoplasm Peroxisomal Membrane Endoplasmic Reticulum Membrane Cytosol Integral Component Of Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Collagen Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength Platelet-derived Growth Factor Binding	Aldehyde Dehydrogenase (NAD+) Activity Protein Binding Protein Homodimerization Activity Glyceraldehyde-3-phosphate Dehydrogenase (NAD+) (non-phosphorylating) Activity Long-chain-alcohol Oxidase Activity Long-chain-aldehyde Dehydrogenase Activity Medium-chain-aldehyde Dehydrogenase Activity
	Biological Process	Osteoblast Differentiation Cell Adhesion Endodermal Cell Differentiation Cellular Response To Amino Acid Stimulus	Cellular Aldehyde Metabolic Process Fatty Acid Metabolic Process Central Nervous System Development Peripheral Nervous System Development Epidermis Development Phytol Metabolic Process Hexadecanal Metabolic Process
Pathways		Collagen degradation Collagen biosynthesis and modifying enzymes Signaling by PDGF Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions ECM proteoglycans ECM proteoglycans NCAM1 interactions Collagen chain trimerization	RND2 GTPase cycle RND1 GTPase cycle
Drugs			NADH
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Bone mineral density (lumbar spine) in inflammatory bowel disease ( 29603369) Corneal hysteresis ( 32716492 30894546) Corneal resistance factor ( 31246245 32716492 30894546) Daytime nap ( 33568662) Diverticular disease ( 30177863) Intraocular pressure ( 29617998 29235454) Keratoconus ( 33649486) Myopia ( 27182965) Pulse pressure ( 30224653 30578418) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Systolic blood pressure ( 28234671) Waist circumference adjusted for body mass index ( 34021172 25673412)
Interacting Genes		24 interacting genes: ALDH3A2 CFAP410 COL2A1 COL6A2 CSTB DCN DNAJB11 FAM3B FGF7 HCFC2 LAMB1 LCMT2 LGALS3BP MAG MLLT3 MPRIP MTDH PCNT PDGFA PDGFB PDK1 PEX26 PIGS RUNX1	2 interacting genes: COL6A1 DISC1
Entrez ID		1291	224
HPRD ID		00370	07188
Ensembl ID		ENSG00000142156	ENSG00000072210
Uniprot IDs		A0A384P5H7 P12109	P51648
PDB IDs			4QGK
Enriched GO Terms of Interacting Partners?
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