KLK2 and SERPINA5

Number of citations of the paper that reports this interaction (PubMedID 9368023)
10

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		KLK2	SERPINA5
Description		kallikrein related peptidase 2	serpin family A member 5
Image
GO Annotations	Cellular Component	Extracellular Region Secretory Granule Extracellular Exosome	Acrosomal Membrane Extracellular Region Extracellular Space External Side Of Plasma Membrane Membrane Platelet Alpha Granule Platelet Dense Tubular Network Protein-containing Complex Protein C Inhibitor-TMPRSS7 Complex Protein C Inhibitor-TMPRSS11E Complex Protein C Inhibitor-PLAT Complex Protein C Inhibitor-PLAU Complex Protein C Inhibitor-thrombin Complex Protein C Inhibitor-KLK3 Complex Protein C Inhibitor-plasma Kallikrein Complex Collagen-containing Extracellular Matrix Extracellular Exosome Protein C Inhibitor-coagulation Factor V Complex Protein C Inhibitor-coagulation Factor Xa Complex Protein C Inhibitor-coagulation Factor XI Complex
	Molecular Function	Serine-type Endopeptidase Activity	Retinoic Acid Binding Protease Binding Serine-type Endopeptidase Inhibitor Activity Protein Binding Glycosaminoglycan Binding Heparin Binding Phosphatidylcholine Binding Acrosin Binding
	Biological Process	Regulation Of Systemic Arterial Blood Pressure Zymogen Activation	Lipid Transport Spermatogenesis Fusion Of Sperm To Egg Plasma Membrane Involved In Single Fertilization Negative Regulation Of Endopeptidase Activity Negative Regulation Of Hydrolase Activity Seminal Vesicle Development
Pathways		Activation of Matrix Metalloproteinases Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	Intrinsic Pathway of Fibrin Clot Formation Common Pathway of Fibrin Clot Formation
Drugs			Urokinase Drotrecogin alfa Tifuvirtide PPL-100
Diseases
GWAS		Celiac disease ( 23936387) PCA3 expression level ( 23555189) Prostate cancer ( 31562322 34012061) Prostate-specific antigen levels ( 23359319 28139693) Prostate-specific antigen levels (conditioned on lead SNPs) ( 28139693) Tandem gait ( 26219847)	Blood protein levels ( 30072576 29875488 28240269) Serum albumin level ( 29403010) Serum total protein level ( 29403010)
Interacting Genes		16 interacting genes: A2M APP AR IGFBP2 JADE2 MET POLR2A SEMG1 SEMG2 SERPINA3 SERPINA4 SERPINA5 SERPINB6 SERPINC1 SERPINE1 SERPINF2	23 interacting genes: ACR CBL COPS6 EPS8 F10 F11 F2 FBLN5 FGA FGB FGG KLK1 KLK2 KLK3 KLKB1 PIAS4 PLAT PLAU PROC RCHY1 RIDA SEMG2 THBD
Entrez ID		3817	5104
HPRD ID		01006	03503
Ensembl ID		ENSG00000167751	ENSG00000188488
Uniprot IDs		A0A024R4J4 A0A024R4N3 B4DU77 P20151	A0A024R6N9 B4DDH1 P05154
PDB IDs		4NFE 4NFF	1LQ8 1PAI 2HI9 2OL2 2PAI 3DY0
Enriched GO Terms of Interacting Partners?
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