KLK2 and SERPINB6

Number of citations of the paper that reports this interaction (PubMedID 26186194)
524

Data Source:
BioGRID (affinity chromatography technology, pull down)
HPRD (in vitro)

		KLK2	SERPINB6
Description		kallikrein related peptidase 2	serpin family B member 6
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Secretory Granule Extracellular Exosome	Extracellular Region Extracellular Space Nucleus Cytoplasm Cytosol Plasma Membrane Secretory Granule Membrane Collagen-containing Extracellular Matrix Extracellular Exosome Tertiary Granule Membrane Serine Protease Inhibitor Complex Ficolin-1-rich Granule Membrane
	Molecular Function	Serine-type Endopeptidase Activity	Protease Binding Serine-type Endopeptidase Inhibitor Activity
	Biological Process	Regulation Of Systemic Arterial Blood Pressure Zymogen Activation	Sensory Perception Of Sound Negative Regulation Of Endopeptidase Activity Cellular Response To Osmotic Stress
Pathways		Activation of Matrix Metalloproteinases Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	Neutrophil degranulation Dissolution of Fibrin Clot
Drugs			Drotrecogin alfa
Diseases
GWAS		Celiac disease ( 23936387) PCA3 expression level ( 23555189) Prostate cancer ( 31562322 34012061) Prostate-specific antigen levels ( 23359319 28139693) Prostate-specific antigen levels (conditioned on lead SNPs) ( 28139693) Tandem gait ( 26219847)	Chronic lymphocytic leukemia ( 26956414) Crohn's disease ( 32581322)
Interacting Genes		16 interacting genes: A2M APP AR IGFBP2 JADE2 MET POLR2A SEMG1 SEMG2 SERPINA3 SERPINA4 SERPINA5 SERPINB6 SERPINC1 SERPINE1 SERPINF2	8 interacting genes: F10 F2 KLK2 MYCBP2 PLAU PLG PROC SUMO2
Entrez ID		3817	5269
HPRD ID		01006	01413
Ensembl ID		ENSG00000167751	ENSG00000124570
Uniprot IDs		A0A024R4J4 A0A024R4N3 B4DU77 P20151	A0A024QZX3 A0A024QZX5 A0A087X1N8 A0A2R8YD12 P35237
PDB IDs		4NFE 4NFF
Enriched GO Terms of Interacting Partners?
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