KCNMA1 and GGT1

Number of citations of the paper that reports this interaction (PubMedID 15528406)
133

Data Source:
HPRD (in vitro)

		KCNMA1	GGT1
Description		potassium calcium-activated channel subfamily M alpha 1	gamma-glutamyltransferase 1
Image
GO Annotations	Cellular Component	Plasma Membrane Caveola Voltage-gated Potassium Channel Complex Integral Component Of Membrane Apical Plasma Membrane Postsynaptic Membrane	Extracellular Space Plasma Membrane Integral Component Of Membrane Extracellular Exosome
	Molecular Function	Actin Binding Voltage-gated Potassium Channel Activity Protein Binding Calcium-activated Potassium Channel Activity Metal Ion Binding Large Conductance Calcium-activated Potassium Channel Activity	Peptidyltransferase Activity Leukotriene-C(4) Hydrolase Protein Binding Glutathione Hydrolase Activity Hypoglycin A Gamma-glutamyl Transpeptidase Activity Leukotriene C4 Gamma-glutamyl Transferase Activity
	Biological Process	Response To Hypoxia Potassium Ion Transport Response To Osmotic Stress Cellular Potassium Ion Homeostasis Response To Carbon Monoxide Regulation Of Ion Transmembrane Transport Regulation Of Membrane Potential Positive Regulation Of Apoptotic Process Negative Regulation Of Cell Volume Response To Calcium Ion Micturition Smooth Muscle Contraction Involved In Micturition Relaxation Of Vascular Associated Smooth Muscle Potassium Ion Transmembrane Transport	Regulation Of Immune System Process Translation Proteolysis Cellular Amino Acid Metabolic Process Glutamate Metabolic Process Fatty Acid Metabolic Process Leukotriene Metabolic Process Glutathione Biosynthetic Process Glutathione Catabolic Process Spermatogenesis Cysteine Biosynthetic Process Peptide Modification Zymogen Activation Response To Estradiol Response To Lipopolysaccharide Response To Tumor Necrosis Factor Regulation Of Inflammatory Response Leukotriene D4 Biosynthetic Process
Pathways		Ca2+ activated K+ channels cGMP effects Sensory processing of sound by inner hair cells of the cochlea Acetylcholine inhibits contraction of outer hair cells	Glutathione synthesis and recycling Synthesis of Leukotrienes (LT) and Eoxins (EX) Aflatoxin activation and detoxification Defective GGT1 causes GLUTH Defective GGT1 in aflatoxin detoxification causes GLUTH LTC4-CYSLTR mediated IL4 production
Drugs		Chlorzoxazone Bendroflumethiazide Procaine Hydroflumethiazide Hydrochlorothiazide Miconazole Diazoxide Halothane Dequalinium Trimebutine	Glutathione
Diseases
GWAS		3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Bell's palsy ( 33602968) Blood pressure ( 24954895) Bone mineral density (spine) ( 26911590) Educational attainment ( 25201988) Estimated glomerular filtration rate ( 31152163 31015462) Glucocorticoid-induced osteonecrosis ( 26265699) Gut microbiota relative abundance (Faecalibacterium) ( 33208821) Heel bone mineral density ( 30598549 28869591) Hypospadias ( 25108383) Initial pursuit acceleration ( 29064472) Intraocular pressure ( 31959993) Lean body mass ( 28552196) Lumbar spine bone mineral density ( 29499414 22504420) Male-pattern baldness ( 28196072) Mortality in heart failure ( 20400778) Myopia ( 27182965) Obesity ( 21708048) Refractive error ( 32231278) Response to ranibizumab in age-related macular degeneration (exudative) ( 30054556) Schizophrenia ( 33169155) Smoking cessation in chronic obstructive pulmonary disease ( 29631575) Spherical equivalent or myopia (age of diagnosis) ( 29808027)	Acne (severe) ( 24927181) Blood metabolite levels ( 24816252) Blood protein levels ( 23696881) Gamma glutamyl transferase levels ( 29403010 33339817 32084209) Gamma glutamyl transpeptidase ( 21909109) Hematological and biochemical traits ( 20139978) Liver enzyme levels ( 18940312) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514 22001757) Protein quantitative trait loci ( 18464913) Serum metabolite levels ( 33031748 23093944) Urinary metabolite levels in chronic kidney disease ( 31959995) Urinary metabolite modules (eigenmetabolites) in chronic kidney disease ( 31959995)
Interacting Genes		7 interacting genes: CACNA1H GGT1 HMOX2 KCNMB1 MAP1A PTK2 SFTPD	4 interacting genes: ADORA2A CD53 KCNMA1 NAMPT
Entrez ID		3778	2678
HPRD ID		15967	01980
Ensembl ID		ENSG00000156113	ENSG00000100031
Uniprot IDs		A0A087WZL8 A0A1W2PP94 A0A1W2PPY5 A0A1W2PQK5 A0A1W2PQU4 A0A1W2PR56 A0A1W2PR62 A0A1W2PRN5 A0A1W2PSD3 B7ZMF5 D5MRH1 Q12791 Q59FH2 Q5SVJ7 S4R453	A0A140VJJ9 P19440
PDB IDs		2K44 3MT5 3NAF 6ND0 6V22 6V35 6V38 6V3G 6V5A	4GDX 4GG2 4Z9O 4ZBK 4ZC6 4ZCG 5V4Q
Enriched GO Terms of Interacting Partners?
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