GGT1

Description		gamma-glutamyltransferase 1
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GO Annotations	Cellular Component	Extracellular Space Plasma Membrane Integral Component Of Membrane Extracellular Exosome
	Molecular Function	Peptidyltransferase Activity Leukotriene-C(4) Hydrolase Protein Binding Glutathione Hydrolase Activity Hypoglycin A Gamma-glutamyl Transpeptidase Activity Leukotriene C4 Gamma-glutamyl Transferase Activity
	Biological Process	Regulation Of Immune System Process Translation Proteolysis Cellular Amino Acid Metabolic Process Glutamate Metabolic Process Fatty Acid Metabolic Process Leukotriene Metabolic Process Glutathione Biosynthetic Process Glutathione Catabolic Process Spermatogenesis Cysteine Biosynthetic Process Peptide Modification Zymogen Activation Response To Estradiol Response To Lipopolysaccharide Response To Tumor Necrosis Factor Regulation Of Inflammatory Response Leukotriene D4 Biosynthetic Process
Pathways		Glutathione synthesis and recycling Synthesis of Leukotrienes (LT) and Eoxins (EX) Aflatoxin activation and detoxification Defective GGT1 causes GLUTH Defective GGT1 in aflatoxin detoxification causes GLUTH LTC4-CYSLTR mediated IL4 production
Drugs		Glutathione
Diseases
GWAS		Acne (severe) ( 24927181) Blood metabolite levels ( 24816252) Blood protein levels ( 23696881) Gamma glutamyl transferase levels ( 29403010 33339817 32084209) Gamma glutamyl transpeptidase ( 21909109) Hematological and biochemical traits ( 20139978) Liver enzyme levels ( 18940312) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514 22001757) Protein quantitative trait loci ( 18464913) Serum metabolite levels ( 33031748 23093944) Urinary metabolite levels in chronic kidney disease ( 31959995) Urinary metabolite modules (eigenmetabolites) in chronic kidney disease ( 31959995)
Interacting Genes		4 interacting genes: ADORA2A CD53 KCNMA1 NAMPT
Entrez ID		2678
HPRD ID		01980
Ensembl ID		ENSG00000100031
Uniprot IDs		A0A140VJJ9 P19440
PDB IDs		4GDX 4GG2 4Z9O 4ZBK 4ZC6 4ZCG 5V4Q
Enriched GO Terms of Interacting Partners?
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