KCNJ11 and ABCC8

Number of citations of the paper that reports this interaction (PubMedID 7502040)
394

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		KCNJ11	ABCC8
Description		potassium inwardly rectifying channel subfamily J member 11	ATP binding cassette subfamily C member 8
Image
GO Annotations	Cellular Component	Acrosomal Vesicle Nuclear Envelope Mitochondrion Endosome Endoplasmic Reticulum Cytosol Plasma Membrane Integral Component Of Plasma Membrane Inward Rectifying Potassium Channel Intercalated Disc T-tubule Axolemma Neuronal Cell Body Myelin Sheath Cell Body Fiber	Mitochondrion Plasma Membrane Inward Rectifying Potassium Channel Membrane Synaptic Vesicle Membrane Potassium Ion-transporting ATPase Complex Sarcolemma
	Molecular Function	Inward Rectifier Potassium Channel Activity Voltage-gated Potassium Channel Activity Protein Binding ATP Binding Protein C-terminus Binding ATP-activated Inward Rectifier Potassium Channel Activity ATPase-coupled Cation Transmembrane Transporter Activity Ankyrin Binding Potassium Ion Binding Heat Shock Protein Binding Transmembrane Transporter Binding	Potassium Channel Activity ATP Binding Sulfonylurea Receptor Activity ATP-activated Inward Rectifier Potassium Channel Activity ATPase-coupled Cation Transmembrane Transporter Activity ATPase-coupled Transmembrane Transporter Activity Transmembrane Transporter Binding ABC-type Transporter Activity
	Biological Process	Response To Ischemia Glucose Metabolic Process Response To Xenobiotic Stimulus Response To Estradiol Response To ATP Response To Testosterone Regulation Of Ion Transmembrane Transport Regulation Of Membrane Potential Negative Regulation Of Insulin Secretion Regulation Of Insulin Secretion Nervous System Process Cellular Response To Nicotine Cellular Response To Glucose Stimulus Cellular Response To Tumor Necrosis Factor Potassium Ion Transmembrane Transport Inorganic Cation Transmembrane Transport Positive Regulation Of Protein Localization To Plasma Membrane Potassium Ion Import Across Plasma Membrane Positive Regulation Of Cation Channel Activity	Cellular Glucose Homeostasis Potassium Ion Transport Female Pregnancy Memory Visual Learning Response To PH Response To Xenobiotic Stimulus Response To Zinc Ion Negative Regulation Of Low-density Lipoprotein Particle Clearance Negative Regulation Of Angiogenesis Response To Lipopolysaccharide Positive Regulation Of Tumor Necrosis Factor Production Response To Insulin Negative Regulation Of Insulin Secretion Transmembrane Transport Negative Regulation Of Glial Cell Proliferation Negative Regulation Of Wound Healing Negative Regulation Of Neuroblast Migration Cellular Response To Organic Substance Potassium Ion Transmembrane Transport Inorganic Cation Transmembrane Transport Positive Regulation Of Uterine Smooth Muscle Relaxation Positive Regulation Of Voltage-gated Potassium Channel Activity Positive Regulation Of Tight Junction Disassembly Negative Regulation Of Blood-brain Barrier Permeability
Pathways		ATP sensitive Potassium channels ABC-family proteins mediated transport Regulation of insulin secretion Ion homeostasis Defective ABCC9 causes CMD10, ATFB12 and Cantu syndrome Defective ABCC8 can cause hypo- and hyper-glycemias	ATP sensitive Potassium channels Regulation of insulin secretion Defective ABCC8 can cause hypo- and hyper-glycemias
Drugs		Glimepiride Ibutilide Verapamil Tolazamide Levosimendan Glyburide Glyburide Diazoxide Thiamylal Yohimbine Butamben Isavuconazole	ATP Glimepiride Chlorpropamide Nateglinide Tolazamide Repaglinide Glyburide Glipizide Gliclazide Tolbutamide Gliquidone Mitiglinide Glymidine
Diseases
GWAS		Body mass index ( 26426971 28892062 25673413 29273807) Circulating leptin levels or type 2 diabetes ( 32341051) Mean arterial pressure ( 27618448) Medication use (drugs used in diabetes) ( 31015401) Pulse pressure ( 27618448 30578418) Social communication problems ( 24564958) Systolic blood pressure ( 27618448 30578418) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Type 2 diabetes ( 22885922 18372903 24509480 30054458 29358691 30297969 29632382 31118516 32499647 17463246 30718926 17463248 17463249 28869590 19056611) Type 2 diabetes (adjusted for BMI) ( 29632382)	Academic attainment (English) ( 33594131) Alcohol dependence symptom count ( 29460428) Body mass index ( 26426971) Circulating leptin levels or type 2 diabetes ( 32341051) Gout ( 22179738) Mean arterial pressure ( 27618448) Metabolite levels ( 23823483) Two-hour glucose ( 34059833) Type 2 diabetes ( 29632382 32499647) Type 2 diabetes (adjusted for BMI) ( 29632382) Weight ( 34074324)
Interacting Genes		7 interacting genes: ABCC8 ABCC9 AP2M1 EXOSC8 KCNJ2 KCNJ8 LDHA	5 interacting genes: CRYBB1 ENSA F2RL1 KCNJ11 KCNJ8
Entrez ID		3767	6833
HPRD ID		09022	02741
Ensembl ID		ENSG00000187486	ENSG00000006071
Uniprot IDs		B2RC52 Q14654	Q09428
PDB IDs		6C3O 6C3P	6C3O 6C3P
Enriched GO Terms of Interacting Partners?
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