KCNJ11 and LDHA

Number of citations of the paper that reports this interaction (PubMedID 12145195)
44

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		KCNJ11	LDHA
Description		potassium inwardly rectifying channel subfamily J member 11	lactate dehydrogenase A
Image
GO Annotations	Cellular Component	Acrosomal Vesicle Nuclear Envelope Mitochondrion Endosome Endoplasmic Reticulum Cytosol Plasma Membrane Integral Component Of Plasma Membrane Inward Rectifying Potassium Channel Intercalated Disc T-tubule Axolemma Neuronal Cell Body Myelin Sheath Cell Body Fiber	Nucleus Cytosol Membrane Extracellular Exosome
	Molecular Function	Inward Rectifier Potassium Channel Activity Voltage-gated Potassium Channel Activity Protein Binding ATP Binding Protein C-terminus Binding ATP-activated Inward Rectifier Potassium Channel Activity ATPase-coupled Cation Transmembrane Transporter Activity Ankyrin Binding Potassium Ion Binding Heat Shock Protein Binding Transmembrane Transporter Binding	L-lactate Dehydrogenase Activity Protein Binding Kinase Binding Identical Protein Binding Cadherin Binding NAD Binding
	Biological Process	Response To Ischemia Glucose Metabolic Process Response To Xenobiotic Stimulus Response To Estradiol Response To ATP Response To Testosterone Regulation Of Ion Transmembrane Transport Regulation Of Membrane Potential Negative Regulation Of Insulin Secretion Regulation Of Insulin Secretion Nervous System Process Cellular Response To Nicotine Cellular Response To Glucose Stimulus Cellular Response To Tumor Necrosis Factor Potassium Ion Transmembrane Transport Inorganic Cation Transmembrane Transport Positive Regulation Of Protein Localization To Plasma Membrane Potassium Ion Import Across Plasma Membrane Positive Regulation Of Cation Channel Activity	Response To Hypoxia Lactate Metabolic Process Glycolytic Process Response To Nutrient Response To Xenobiotic Stimulus Response To Glucose NAD Metabolic Process Response To Hydrogen Peroxide Positive Regulation Of Apoptotic Process Response To Estrogen Post-embryonic Animal Organ Development Response To CAMP
Pathways		ATP sensitive Potassium channels ABC-family proteins mediated transport Regulation of insulin secretion Ion homeostasis Defective ABCC9 causes CMD10, ATFB12 and Cantu syndrome Defective ABCC8 can cause hypo- and hyper-glycemias	Pyruvate metabolism
Drugs		Glimepiride Ibutilide Verapamil Tolazamide Levosimendan Glyburide Glyburide Diazoxide Thiamylal Yohimbine Butamben Isavuconazole	NADH Etheno-NAD Nicotinamide Oxamic Acid Stiripentol Copper Artenimol
Diseases
GWAS		Body mass index ( 26426971 28892062 25673413 29273807) Circulating leptin levels or type 2 diabetes ( 32341051) Mean arterial pressure ( 27618448) Medication use (drugs used in diabetes) ( 31015401) Pulse pressure ( 27618448 30578418) Social communication problems ( 24564958) Systolic blood pressure ( 27618448 30578418) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Type 2 diabetes ( 22885922 18372903 24509480 30054458 29358691 30297969 29632382 31118516 32499647 17463246 30718926 17463248 17463249 28869590 19056611) Type 2 diabetes (adjusted for BMI) ( 29632382)	Amyloid A serum levels ( 21124955) Serum metabolite levels ( 33031748)
Interacting Genes		7 interacting genes: ABCC8 ABCC9 AP2M1 EXOSC8 KCNJ2 KCNJ8 LDHA	20 interacting genes: ABCC9 ACD DUX4 DYNLL1 FGFR1 GSK3A HNRNPD HULC KCNJ11 LDHB MAPK10 NDRG1 PCNA POT1 PTPRF TERF1 TINF2 UPF2 XRN1 YWHAQ
Entrez ID		3767	3939
HPRD ID		09022	01025
Ensembl ID		ENSG00000187486	ENSG00000134333
Uniprot IDs		B2RC52 Q14654	P00338 V9HWB9
PDB IDs		6C3O 6C3P	1I10 4AJP 4JNK 4L4R 4L4S 4M49 4OJN 4OKN 4QO7 4QO8 4QSM 4QT0 4R68 4R69 4RLS 4ZVV 5IXS 5IXY 5W8H 5W8I 5W8J 5W8K 5W8L 5ZJD 5ZJE 5ZJF 6BAD 6BAG 6BAX 6BAZ 6BB0 6BB1 6BB2 6BB3 6MV8 6MVA 6Q0D 6Q13 6SBU 6SBV 6ZZR
Enriched GO Terms of Interacting Partners?
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