ABCC8

Description		ATP binding cassette subfamily C member 8
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GO Annotations	Cellular Component	Mitochondrion Plasma Membrane Inward Rectifying Potassium Channel Membrane Synaptic Vesicle Membrane Potassium Ion-transporting ATPase Complex Sarcolemma
	Molecular Function	Potassium Channel Activity ATP Binding Sulfonylurea Receptor Activity ATP-activated Inward Rectifier Potassium Channel Activity ATPase-coupled Cation Transmembrane Transporter Activity ATPase-coupled Transmembrane Transporter Activity Transmembrane Transporter Binding ABC-type Transporter Activity
	Biological Process	Cellular Glucose Homeostasis Potassium Ion Transport Female Pregnancy Memory Visual Learning Response To PH Response To Xenobiotic Stimulus Response To Zinc Ion Negative Regulation Of Low-density Lipoprotein Particle Clearance Negative Regulation Of Angiogenesis Response To Lipopolysaccharide Positive Regulation Of Tumor Necrosis Factor Production Response To Insulin Negative Regulation Of Insulin Secretion Transmembrane Transport Negative Regulation Of Glial Cell Proliferation Negative Regulation Of Wound Healing Negative Regulation Of Neuroblast Migration Cellular Response To Organic Substance Potassium Ion Transmembrane Transport Inorganic Cation Transmembrane Transport Positive Regulation Of Uterine Smooth Muscle Relaxation Positive Regulation Of Voltage-gated Potassium Channel Activity Positive Regulation Of Tight Junction Disassembly Negative Regulation Of Blood-brain Barrier Permeability
Pathways		ATP sensitive Potassium channels Regulation of insulin secretion Defective ABCC8 can cause hypo- and hyper-glycemias
Drugs		ATP Glimepiride Chlorpropamide Nateglinide Tolazamide Repaglinide Glyburide Glipizide Gliclazide Tolbutamide Gliquidone Mitiglinide Glymidine
Diseases
GWAS		Academic attainment (English) ( 33594131) Alcohol dependence symptom count ( 29460428) Body mass index ( 26426971) Circulating leptin levels or type 2 diabetes ( 32341051) Gout ( 22179738) Mean arterial pressure ( 27618448) Metabolite levels ( 23823483) Two-hour glucose ( 34059833) Type 2 diabetes ( 29632382 32499647) Type 2 diabetes (adjusted for BMI) ( 29632382) Weight ( 34074324)
Interacting Genes		5 interacting genes: CRYBB1 ENSA F2RL1 KCNJ11 KCNJ8
Entrez ID		6833
HPRD ID		02741
Ensembl ID		ENSG00000006071
Uniprot IDs		Q09428
PDB IDs		6C3O 6C3P
Enriched GO Terms of Interacting Partners?
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