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ITGAV and CCN1
Number of citations of the paper that reports this interaction (PubMedID
10821835
)
56
Data Source:
BioGRID
(pull down)
HPRD
(in vitro, in vivo)
ITGAV
CCN1
Description
integrin subunit alpha V
cellular communication network factor 1
Image
GO Annotations
Cellular Component
Cytosol
Plasma Membrane
Integral Component Of Plasma Membrane
Focal Adhesion
Integrin Complex
External Side Of Plasma Membrane
Cell Surface
Membrane
Lamellipodium Membrane
Filopodium Membrane
Microvillus Membrane
Ruffle Membrane
Integrin Alphav-beta3 Complex
Integrin Alphav-beta5 Complex
Integrin Alphav-beta6 Complex
Integrin Alphav-beta8 Complex
Specific Granule Membrane
Alphav-beta3 Integrin-PKCalpha Complex
Alphav-beta3 Integrin-IGF-1-IGF1R Complex
Alphav-beta3 Integrin-HMGB1 Complex
Phagocytic Vesicle
Extracellular Exosome
Extracellular Region
Endoplasmic Reticulum Lumen
Extracellular Matrix
Collagen-containing Extracellular Matrix
Molecular Function
Virus Receptor Activity
Opsonin Binding
Fibronectin Binding
Protease Binding
Protein Kinase C Binding
Integrin Binding
Voltage-gated Calcium Channel Activity
Protein Binding
Coreceptor Activity
Fibroblast Growth Factor Binding
C-X3-C Chemokine Binding
Insulin-like Growth Factor I Binding
Neuregulin Binding
Metal Ion Binding
Transforming Growth Factor Beta Binding
Extracellular Matrix Binding
Extracellular Matrix Protein Binding
Integrin Binding
Extracellular Matrix Structural Constituent
Protein Binding
Insulin-like Growth Factor Binding
Heparin Binding
Extracellular Matrix Binding
Biological Process
Angiogenesis
Vasculogenesis
Cell Adhesion
Cell-matrix Adhesion
Positive Regulation Of Cytosolic Calcium Ion Concentration
Integrin-mediated Signaling Pathway
Positive Regulation Of Cell Population Proliferation
Negative Regulation Of Macrophage Derived Foam Cell Differentiation
Negative Regulation Of Lipid Storage
Cell Migration
Positive Regulation Of Cell Migration
Cell-substrate Adhesion
Negative Regulation Of Lipid Transport
Cell Adhesion Mediated By Integrin
Positive Regulation Of Osteoblast Proliferation
Heterotypic Cell-cell Adhesion
Substrate Adhesion-dependent Cell Spreading
Endodermal Cell Differentiation
Apolipoprotein A-I-mediated Signaling Pathway
Apoptotic Cell Clearance
Positive Regulation Of Cell Adhesion
Viral Entry Into Host Cell
Negative Regulation Of Lipoprotein Metabolic Process
Regulation Of Phagocytosis
Negative Chemotaxis
Positive Regulation Of Small GTPase Mediated Signal Transduction
ERK1 And ERK2 Cascade
Calcium Ion Transmembrane Transport
Transforming Growth Factor Beta Production
Entry Into Host Cell By A Symbiont-containing Vacuole
Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Regulation Of Transforming Growth Factor Beta Activation
Positive Regulation Of Intracellular Signal Transduction
Negative Regulation Of Low-density Lipoprotein Receptor Activity
Negative Regulation Of Entry Of Bacterium Into Host Cell
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Osteoblast Differentiation
Positive Regulation Of Protein Phosphorylation
Intussusceptive Angiogenesis
Atrioventricular Valve Morphogenesis
Apoptotic Process Involved In Heart Morphogenesis
Ventricular Septum Development
Chemotaxis
Cell Adhesion
Signal Transduction
Positive Regulation Of Phospholipase Activity
Positive Regulation Of Cell-substrate Adhesion
Extracellular Matrix Organization
Positive Regulation Of Cell Migration
Positive Regulation Of Bone Mineralization
Positive Regulation Of BMP Signaling Pathway
Positive Regulation Of Osteoblast Proliferation
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Wound Healing, Spreading Of Cells
Positive Regulation Of Osteoblast Differentiation
Positive Regulation Of Protein Kinase Activity
Positive Regulation Of Transcription By RNA Polymerase II
Atrial Septum Morphogenesis
Negative Regulation Of Cell Death
Chondroblast Differentiation
Chorio-allantoic Fusion
Labyrinthine Layer Blood Vessel Development
Positive Regulation Of Cartilage Development
Regulation Of ERK1 And ERK2 Cascade
Reactive Oxygen Species Metabolic Process
Positive Regulation Of Ceramide Biosynthetic Process
Pathways
Cross-presentation of particulate exogenous antigens (phagosomes)
Elastic fibre formation
PECAM1 interactions
Molecules associated with elastic fibres
Integrin cell surface interactions
Integrin cell surface interactions
Laminin interactions
Syndecan interactions
Syndecan interactions
ECM proteoglycans
VEGFA-VEGFR2 Pathway
Signal transduction by L1
Neutrophil degranulation
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Post-translational protein phosphorylation
Drugs
Antithymocyte immunoglobulin (rabbit)
Levothyroxine
Diseases
GWAS
Asthma (
32296059
)
Crohn's disease (
28067908
)
Inflammatory bowel disease (
28067908
)
Left-handedness (
32989287
)
Lung function (FEV1/FVC) (
30804560
)
Microalbuminuria (
26631737
)
Urinary albumin-to-creatinine ratio (
26631737
)
Urinary albumin-to-creatinine ratio in non-diabetics (
26631737
)
Appendicular lean mass (
33097823
)
Interacting Genes
33 interacting genes:
ADAM9
ANGPTL3
AUP1
AZGP1
CALR
CCN1
CCN3
CD47
EDIL3
F2R
ICAM4
ITGB1
ITGB3
ITGB5
ITGB6
ITGB8
L1CAM
LGALS3BP
MAPK3
MMP14
MMP2
NID1
P2RY2
PAK4
PDGFRA
PLA2G2A
PLP1
PTK2
PXN
SPP1
TGFB1
THY1
UBC
6 interacting genes:
CDC42
ITGAV
ITGB5
SFTPD
SMPD2
UBQLN2
Entrez ID
3685
3491
HPRD ID
01903
09089
Ensembl ID
ENSG00000138448
ENSG00000142871
Uniprot IDs
L7RXH0
P06756
O00622
Q6FI18
PDB IDs
1JV2
1L5G
1M1X
1U8C
3IJE
4G1E
4G1M
4MMX
4MMY
4MMZ
4O02
4UM8
4UM9
5FFG
5FFO
5NEM
5NER
5NET
5NEU
6AVQ
6AVR
6AVU
6DJP
6MK0
6MSL
6MSU
6NAJ
6OM1
6OM2
6UJA
6UJB
6UJC
4D0Z
4D11
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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