CCN1 and ITGB5

Number of citations of the paper that reports this interaction (PubMedID 11287419)
53

Data Source:
HPRD (in vitro)

		CCN1	ITGB5
Description		cellular communication network factor 1	integrin subunit beta 5
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Endoplasmic Reticulum Lumen Extracellular Matrix Collagen-containing Extracellular Matrix	Plasma Membrane Focal Adhesion Integrin Complex Cell Surface Integrin Alphav-beta5 Complex Receptor Complex Phagocytic Vesicle Extracellular Exosome
	Molecular Function	Integrin Binding Extracellular Matrix Structural Constituent Protein Binding Insulin-like Growth Factor Binding Heparin Binding Extracellular Matrix Binding	Virus Receptor Activity Integrin Binding Protein Binding Signaling Receptor Activity
	Biological Process	Osteoblast Differentiation Positive Regulation Of Protein Phosphorylation Intussusceptive Angiogenesis Atrioventricular Valve Morphogenesis Apoptotic Process Involved In Heart Morphogenesis Ventricular Septum Development Chemotaxis Cell Adhesion Signal Transduction Positive Regulation Of Phospholipase Activity Positive Regulation Of Cell-substrate Adhesion Extracellular Matrix Organization Positive Regulation Of Cell Migration Positive Regulation Of Bone Mineralization Positive Regulation Of BMP Signaling Pathway Positive Regulation Of Osteoblast Proliferation Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Wound Healing, Spreading Of Cells Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Protein Kinase Activity Positive Regulation Of Transcription By RNA Polymerase II Atrial Septum Morphogenesis Negative Regulation Of Cell Death Chondroblast Differentiation Chorio-allantoic Fusion Labyrinthine Layer Blood Vessel Development Positive Regulation Of Cartilage Development Regulation Of ERK1 And ERK2 Cascade Reactive Oxygen Species Metabolic Process Positive Regulation Of Ceramide Biosynthetic Process	Cell-matrix Adhesion Transforming Growth Factor Beta Receptor Signaling Pathway Integrin-mediated Signaling Pathway Cell Migration Cell Adhesion Mediated By Integrin Endodermal Cell Differentiation Stress Fiber Assembly Viral Entry Into Host Cell Epithelial Cell-cell Adhesion
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation	Cross-presentation of particulate exogenous antigens (phagosomes) Molecules associated with elastic fibres Integrin cell surface interactions Integrin cell surface interactions Syndecan interactions Syndecan interactions ECM proteoglycans Smooth Muscle Contraction
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823)	Airway hyperresponsiveness ( 23984888) Carpal tunnel syndrome ( 30833571) Coronary artery disease ( 28714974) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Diastolic blood pressure ( 27841878) Heel bone mineral density ( 30598549) Hip circumference adjusted for BMI ( 34021172) Mean corpuscular hemoglobin concentration ( 32888494) Pulse pressure ( 27841878) Systolic blood pressure ( 27841878 30578418)
Interacting Genes		6 interacting genes: CDC42 ITGAV ITGB5 SFTPD SMPD2 UBQLN2	58 interacting genes: ANXA5 APPBP2 CCN1 CYSRT1 DAB1 DAB2 DOK1 EFEMP2 EHMT2 EPS8 EWSR1 FDFT1 FHL2 FHL3 FLNA GAPDH GOLGA2 GON4L ITGA5 ITGAV ITGB3BP KRT31 KRT34 KRT40 KRTAP1-1 KRTAP1-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP3-2 KRTAP5-7 LTBP1 LTBP3 MTDH MTUS2 MYBPC2 MYO10 NBPF19 NOTCH2NLA NUMB P2RY2 PAK4 PALLD PPARD PTK2 RACK1 SNTA1 SPP1 SRSF9 STAB2 TAF1 TLN1 TNS2 TRIM55 TRIM63 TTN ZBTB17 ZNF655
Entrez ID		3491	3693
HPRD ID		09089	00949
Ensembl ID		ENSG00000142871	ENSG00000082781
Uniprot IDs		O00622 Q6FI18	D3DNA1 L7RT22 P18084
PDB IDs		4D0Z 4D11
Enriched GO Terms of Interacting Partners?
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