IL15 and IL2RG

Number of citations of the paper that reports this interaction (PubMedID 8568232)
15

Data Source:
HPRD (in vivo)

		IL15	IL2RG
Description		interleukin 15	interleukin 2 receptor subunit gamma
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleoplasm Cytoplasm Endosome Golgi Apparatus Cytosol Cell Surface Nuclear Speck	Endosome Cytosol Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Receptor Complex
	Molecular Function	Cytokine Activity Cytokine Receptor Binding Protein Binding	Cytokine Receptor Activity Interleukin-2 Receptor Activity Interleukin-4 Receptor Activity Interleukin-7 Receptor Activity Protein Binding Cytokine Binding Interleukin-2 Binding Interleukin-15 Receptor Activity
	Biological Process	Positive Regulation Of Cytokine Production NK T Cell Proliferation Inflammatory Response Immune Response Signal Transduction Tyrosine Phosphorylation Of STAT Protein Cell-cell Signaling Aging Positive Regulation Of Cell Population Proliferation Skeletal Muscle Atrophy Hyaluronan Metabolic Process Macrophage Differentiation Positive Regulation Of Interleukin-17 Production Positive Regulation Of Natural Killer Cell Proliferation Positive Regulation Of Natural Killer Cell Differentiation Positive Regulation Of Tissue Remodeling Interleukin-15-mediated Signaling Pathway Positive Regulation Of T Cell Proliferation Neutrophil Activation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Extrathymic T Cell Selection Regulation Of T Cell Differentiation Cell Maturation Lymph Node Development Negative Regulation Of Smooth Muscle Cell Proliferation Regulation Of Defense Response To Virus By Host Positive Regulation Of Inflammatory Response Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Phagocytosis Positive Regulation Of Immune Response Cellular Response To Vitamin D Negative Regulation Of Cold-induced Thermogenesis Positive Regulation Of Protein O-linked Glycosylation	Immune Response Signal Transduction Cytokine-mediated Signaling Pathway Interleukin-15-mediated Signaling Pathway Interleukin-4-mediated Signaling Pathway Interleukin-2-mediated Signaling Pathway Interleukin-7-mediated Signaling Pathway Positive Regulation Of Phagocytosis
Pathways		Interleukin-15 signaling Interleukin-15 signaling	Interleukin-7 signaling Interleukin-7 signaling RAF/MAP kinase cascade Interleukin-4 and Interleukin-13 signaling Interleukin-15 signaling Interleukin-15 signaling Interleukin-9 signaling Interleukin-2 signaling Interleukin-21 signaling Interleukin receptor SHC signaling STAT3 nuclear events downstream of ALK signaling
Drugs		Cefazolin	Denileukin diftitox Aldesleukin Resatorvid
Diseases
GWAS		Insomnia ( 29520036) Malaria ( 31844061) Post-traumatic stress disorder symptoms in trauma-exposed soldiers ( 30999091) Response to treatment for acute lymphoblastic leukemia ( 19176441)
Interacting Genes		7 interacting genes: APP IL15RA IL2RB IL2RG POLR1H STAT5B TRAF3	27 interacting genes: AXL CAPNS1 ERRFI1 ICAM1 IL15 IL15RA IL2 IL2RB IL4 IL4R IL7 IL7R IL9R JAK1 JAK3 KRTAP10-3 KRTAP10-8 KRTAP5-7 NOTCH2NLA PTPRJ SHB SHC1 STAT1 STAT5A STK4 WWP1 WWP2
Entrez ID		3600	3561
HPRD ID		02776	02391
Ensembl ID		ENSG00000164136	ENSG00000147168
Uniprot IDs		P40933	P31785
PDB IDs		2XQB 2Z3Q 2Z3R 4GS7	1ILL 1ILM 1ILN 1ITE 2B5I 2ERJ 3BPL 3QAZ 3QB7 4GS7 5M5E 6OEL
Enriched GO Terms of Interacting Partners?
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